سعر ايزوسوربيد 20 مجم 10 اقراص 2022

Isosorbide (isosorbide-5-mononitrate) 20 mg tablets, pack of 10, for prophylaxis of angina pectoris.

• Prevention and treatment of angina pectoris due to coronary artery disease. The onset of action of oral isosorbide mononitrate is not sufficiently rapid for aborting an acute anginal episode.Population: AdultsDailyMed (U.S. National Library of Medicine)

• Headache (most frequent; may cause discontinuation); hypotension and/or light-headedness in the upright position, flushing, dizziness, reflex tachycardia; less often nausea, vomiting and allergic skin reactions.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine), electronic medicines compendium (eMC) / MHRA

• Hypersensitivity to isosorbide mononitrate; concomitant use of PDE5 inhibitors (sildenafil, tadalafil, vardenafil) or riociguat — severe hypotension may result.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Severe hypotension, particularly upright, may occur even with small doses; use caution in volume-depleted or already hypotensive patients. Headache is common and often decreases after the first few days.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• PDE5 inhibitors / riociguatContraindicated; may cause severe hypotension.DailyMed (U.S. National Library of Medicine)
• Other antihypertensives / vasodilators / alcoholMay potentiate the hypotensive effect.electronic medicines compendium (eMC) / MHRA

• Reproduction studies in rats and rabbits at high multiples of the human dose showed no evidence of fetal harm; no adequate studies in pregnant women; use only if clearly needed.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Unknown whether excreted in human milk; caution.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Isosorbide-5-mononitrate: Major active metabolite of isosorbide dinitrate; relaxes vascular smooth muscle, dilating veins and arteries and reducing myocardial oxygen demand.