سعر جستيكول 10مجم 14 قرص 2023

Justechol (rosuvastatin) 10 mg film-coated tablets, pack of 14, by AUG Pharma (Egypt); HMG-CoA reductase inhibitor for lowering cholesterol.

• To reduce the risk of major adverse cardiovascular events (CV death, nonfatal MI, nonfatal stroke, arterial revascularization) in adults at increased risk.Population: Adults at increased cardiovascular riskDailyMed (U.S. National Library of Medicine)
• Adjunct to diet and exercise to reduce LDL-C in adults with primary hypercholesterolemia, to slow progression of atherosclerosis, and in heterozygous (age 8+) or homozygous (age 7+) familial hypercholesterolemia.Population: Adults; pediatric HeFH 8+ years and HoFH 7+ yearsDailyMed (U.S. National Library of Medicine)
• Adjunct to diet for adults with primary dysbetalipoproteinemia or hypertriglyceridemia.Population: AdultsDailyMed (U.S. National Library of Medicine)

• Most frequent adverse reactions (2% or more): headache, nausea, myalgia, asthenia and constipation.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Acute liver failure or decompensated cirrhosis.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Hypersensitivity to rosuvastatin or any excipient (reactions include rash, pruritus, urticaria and angioedema).International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Myopathy and rhabdomyolysis (risk factors: age 65+, uncontrolled hypothyroidism, renal impairment, certain concomitant drugs, higher dose, Asian patients); discontinue if markedly elevated CK or myopathy diagnosed/suspected; report unexplained muscle pain, tenderness or weakness.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Immune-mediated necrotizing myopathy has rarely been reported with statins; discontinue if suspected.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Hepatic dysfunction: transaminase increases and rare hepatic failure; consider liver enzyme testing before initiation and as clinically indicated; discontinue if serious hepatic injury occurs.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• CyclosporineDo not exceed rosuvastatin 5 mg once daily (increased exposure and myopathy risk).DailyMed (U.S. National Library of Medicine)
• GemfibrozilAvoid concomitant use; if unavoidable, start 5 mg once daily and do not exceed 10 mg once daily.DailyMed (U.S. National Library of Medicine)
• Sofosbuvir/velpatasvir/voxilaprevir or ledipasvir/sofosbuvirAvoid concomitant use.DailyMed (U.S. National Library of Medicine)

• May cause fetal harm based on mechanism of action; discontinue when pregnancy is recognized (or consider the ongoing therapeutic needs of the individual patient). Observational data with statins have not identified a drug-associated risk of major congenital malformations.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Rosuvastatin is present in human milk (limited data); breastfeeding is not recommended during treatment.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Rosuvastatin: Inhibits HMG-CoA reductase, decreasing cholesterol synthesis (US CRESTOR label).