سعر كابيفكتين 250مجم 14 قرص 2023

Kapifectin 250 mg film-coated tablets (clarithromycin), pack of 14, Eva Pharma, Egypt.

• Mild to moderate infections caused by susceptible bacteria: acute bacterial exacerbation of chronic bronchitis, acute maxillary sinusitis, community-acquired pneumonia, pharyngitis/tonsillitis, uncomplicated skin and skin-structure infections.Population: AdultsDailyMed (U.S. National Library of Medicine)
• Acute otitis media in paediatric patients; treatment and prophylaxis of disseminated mycobacterial infections.Population: Adults and paediatric patientsDailyMed (U.S. National Library of Medicine)
• Helicobacter pylori infection and duodenal ulcer disease in adults (in combination regimens).Population: AdultsDailyMed (U.S. National Library of Medicine)

• Most frequent adverse reactions: abdominal pain, diarrhoea, nausea, vomiting and dysgeusia.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Hypersensitivity to clarithromycin or any macrolide; history of cholestatic jaundice/hepatic dysfunction with clarithromycin; coadministration with cisapride, pimozide, lomitapide, lovastatin, simvastatin, ergot alkaloids (ergotamine, dihydroergotamine) or lurasidone; colchicine in patients with renal or hepatic impairment.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• QT prolongation: avoid in known QT prolongation, ventricular arrhythmia (torsades de pointes), uncorrected hypokalaemia/hypomagnesaemia, significant bradycardia or with class IA/III antiarrhythmics or other QT-prolonging drugs.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Hepatotoxicity (discontinue if hepatitis occurs); severe acute hypersensitivity reactions; Clostridioides difficile-associated diarrhoea; exacerbation of myasthenia gravis.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Increased all-cause mortality one year or more after treatment in patients with coronary artery disease; balance risk and benefit.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• CYP3A substrates (e.g. colchicine, some statins, some calcium-channel blockers)Clarithromycin can increase concentrations of co-administered drugs; serious reactions have occurred with colchicine, some lipid-lowering agents and calcium-channel blockers.DailyMed (U.S. National Library of Medicine)

• Based on animal findings, not recommended in pregnant women except where no alternative therapy is appropriate; inform the patient of the potential fetal hazard if pregnancy occurs.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Clarithromycin and 14-OH clarithromycin appear in human milk at < 2% of the maternal weight-adjusted dose; reported infant effects (rash, diarrhoea, loss of appetite, somnolence) were comparable to amoxicillin.International label, same formulation · DailyMed (U.S. National Library of Medicine)

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