سعر كوكاست 10مجم 10 اقراص 2024

Montelukast 10 mg film-coated tablets, pack of 10 (Kokast, Egyphar, Egypt); oral leukotriene receptor antagonist.

• Prophylaxis and chronic treatment of asthma.Population: Adults and adolescents 15 years and olderDailyMed (U.S. National Library of Medicine)
• Relief of symptoms of seasonal and perennial allergic rhinitis, reserved for patients with inadequate response or intolerance to alternative therapies.Population: Adults and adolescents 15 years and olderDailyMed (U.S. National Library of Medicine)
• Prevention of exercise-induced bronchoconstriction.Population: Adults and adolescents 15 years and olderDailyMed (U.S. National Library of Medicine)

• Reported in controlled trials: upper respiratory infection, headache, abdominal pain, cough and influenza in adults/adolescents; in children also fever, pharyngitis, diarrhoea and otitis media.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Hypersensitivity to any of its components.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Boxed warning: serious neuropsychiatric events (e.g. agitation, aggression, depression, sleep disturbances, suicidal thoughts and behaviour) have been reported; weigh benefits and risks and stop the drug and seek care if they occur.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Not for reversal of bronchospasm in acute asthma attacks; patients should have rescue medication available.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Do not abruptly substitute for inhaled or oral corticosteroids.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Theophylline, prednisone, oral contraceptives, warfarin, digoxin, CYP450 inducers and othersNo dose adjustment is needed when co-administered with these drugs.DailyMed (U.S. National Library of Medicine)

• Published cohort data over decades have not established a drug-associated risk of major birth defects; no adverse developmental effects in animal studies. Poorly controlled asthma itself increases maternal and fetal risks.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Montelukast is present in human milk; available data do not suggest a significant risk to the breastfed infant.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Montelukast: Selective, orally active antagonist of the cysteinyl leukotriene CysLT1 receptor; inhibits LTD4 actions without agonist activity (US label 12.1).