سعر كوناكيون ام ام 10مجم/مل 5 امبولات وريد / فم 2022

Konakion MM phytomenadione (vitamin K1) 10 mg/ml mixed-micelle solution, 5 ampoules, labelled in Egypt for IV/oral use (Roche, Multipharma).

• Antidote to coumarin-type anticoagulants in the treatment of haemorrhage or threatened haemorrhage associated with low prothrombin or factor VII (UK SmPC, same product name and strength).Population: Adults and children (specialist advice)electronic medicines compendium (emc)

• Anaphylactoid reactions after IV injection; very rarely venous irritation or phlebitis.International label, same formulation · electronic medicines compendium (emc)

• Hypersensitivity to any constituent. Must not be given intramuscularly (depot effect hinders re-anticoagulation; risk of haematoma in anticoagulated patients).International label, same formulation · electronic medicines compendium (emc)

• Give slowly IV and not more than 40 mg in 24 hours in severe coumarin overdose, accompanied by more immediate measures (blood or clotting factors); avoid large doses if anticoagulation is to continue; vitamin K1 is not an antidote to heparin; avoid in mechanical heart valves unless major bleeding; do not use turbid or separated ampoules.International label, same formulation · electronic medicines compendium (emc)

• Coumarin anticoagulants (e.g. warfarin)Antagonises coumarin anticoagulants; no other significant interactions known.electronic medicines compendium (emc)

• No specific evidence on safety in pregnancy; use only if benefits outweigh risks. Not recommended for pregnant women as prophylaxis of vitamin K deficiency bleeding in the newborn.International label, same formulation · electronic medicines compendium (emc)

• Phytomenadione (vitamin K1): Cofactor for the hepatic synthesis of vitamin K-dependent clotting factors (II, VII, IX, X); antagonises coumarin anticoagulants.