سعر Hithrombin 10 mg/ml 5 ampoules for i.m./i.v. injection 2026

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• Coagulation disorders from vitamin K deficiency or interference: anticoagulant-induced hypoprothrombinaemia, hypoprothrombinaemia due to antibacterials or impaired absorption/synthesis; prophylaxis and treatment of vitamin K deficiency bleeding in neonates.Population: Adults and neonatesDailyMed (U.S. National Library of Medicine)

• Most common: cyanosis, diaphoresis, dizziness, dysgeusia, dyspnoea, flushing, hypotension and tachycardia; serious hypersensitivity and cutaneous reactions.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Hypersensitivity to phytonadione or any component.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Boxed warning: fatal hypersensitivity reactions including anaphylaxis with IV and IM use, even with dilution and on first dose; avoid IV/IM unless SC not feasible and risk justified. Benzyl alcohol risk in infants; cutaneous reactions possible.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Published data have not shown a clear association with adverse outcomes; product contains benzyl alcohol, consider a benzyl-alcohol-free formulation if needed in pregnancy.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Phytonadione is present in breast milk; no data on effects on the breastfed child; preservative-free formulation recommended during lactation if available.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Phytomenadione (vitamin K1): Cofactor for hepatic gamma-carboxylation of coagulation factors II, VII, IX and X.