سعر لانفيس 40 مجم 25 قرص 2022

Lanvis thioguanine 40 mg tablets, pack of 25 (Phoenix Group, Egypt); antimetabolite for acute myeloid leukaemia.

• Remission induction and remission consolidation treatment of acute nonlymphocytic (myeloid) leukaemia; not recommended for maintenance or long-term continuous therapy.Population: Adults and children (specialist use)DailyMed (U.S. National Library of Medicine)

• Most frequent adverse reaction is myelosuppression (leucopenia, thrombocytopenia, anaemia, pancytopenia); also hepatotoxicity and gastrointestinal effects.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Patients whose disease has demonstrated prior resistance to thioguanine (complete cross-resistance with mercaptopurine usually exists).International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Not recommended for long-term continuous therapy because of a high risk of liver toxicity, including hepatic veno-occlusive disease/portal hypertension, especially in males; stop if signs of liver toxicity appear.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Myelosuppression is the most consistent dose-related toxicity; TPMT or NUDT15 deficiency increases the risk of severe toxicity.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Aminosalicylate derivatives (e.g. olsalazine, mesalazine, sulfasalazine)May inhibit TPMT and increase thioguanine toxicity; use with caution.DailyMed (U.S. National Library of Medicine)
• MercaptopurineUsually complete cross-resistance between thioguanine and mercaptopurine.DailyMed (U.S. National Library of Medicine)

• It is not known whether thioguanine is excreted in human milk; because of potential serious adverse reactions and tumorigenicity, decide whether to discontinue nursing or the drug.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Thioguanine (tioguanine): Guanine analogue converted to thioguanine nucleotides that are incorporated into DNA and RNA and interfere with purine synthesis.