سعر ايوبيفلودا 10 مجم 5 أقراص 2022

Fludarabine 10 mg film-coated tablets, pack of 5 (Eupifluda; Hikma Specialized Pharmaceuticals); listed as not yet available.

• B-cell chronic lymphocytic leukaemia (CLL) in adults with sufficient bone marrow reserves; first-line only in advanced disease (Rai III/IV, Binet C) or Rai I/II (Binet A/B) with disease-related symptoms or progressive disease.Population: Adultselectronic medicines compendium (eMC), United Kingdom

• Very common: neutropenia, anaemia, thrombocytopenia, infections/opportunistic infections including pneumonia, cough, vomiting, diarrhoea, nausea, fever, fatigue, weakness. Common: myelosuppression, myelodysplastic syndrome and AML (mainly with prior/concomitant alkylating agents, topoisomerase inhibitors or irradiation), anorexia, peripheral neuropathy, visual disturbances, stomatitis, rash, oedema, mucositis, chills, malaise.International label, same formulation · electronic medicines compendium (eMC), United Kingdom

• Hypersensitivity to fludarabine or any excipient; renal impairment with creatinine clearance <30 ml/min; decompensated haemolytic anaemia; lactation.International label, same formulation · electronic medicines compendium (eMC), United Kingdom

• Severe, sometimes cumulative bone marrow suppression (anaemia, thrombocytopenia, neutropenia), including fatal trilineage aplasia; life-threatening autoimmune phenomena (e.g. autoimmune haemolytic anaemia) – discontinue in case of haemolysis.International label, same formulation · electronic medicines compendium (eMC), United Kingdom
• Neurotoxicity including leukoencephalopathy, acute toxic leukoencephalopathy or RPLS (stop treatment if suspected); tumour lysis syndrome in patients with large tumour burden; transfusion-associated graft-versus-host disease – use only irradiated blood products.International label, same formulation · electronic medicines compendium (eMC), United Kingdom
• Avoid live vaccines during and after treatment. Women of childbearing potential must use effective contraception during and for at least 6 months after therapy; men for at least 3 months after treatment.International label, same formulation · electronic medicines compendium (eMC), United Kingdom

• Pentostatin (deoxycoformycin)AvoidCombination with pentostatin in refractory CLL caused an unacceptably high incidence of fatal pulmonary toxicity; not recommended.electronic medicines compendium (eMC), United Kingdom
• Dipyridamole and other adenosine uptake inhibitorsMay reduce the therapeutic efficacy of fludarabine.electronic medicines compendium (eMC), United Kingdom
• CytarabineFludarabine increased intracellular peak concentration and exposure of Ara-CTP (active cytarabine metabolite) in leukaemic cells.electronic medicines compendium (eMC), United Kingdom

• Fludarabine phosphate is genotoxic and embryotoxic/fetotoxic in rats and rabbits and may cause foetal harm; must not be used during pregnancy unless clearly necessary (benefit outweighs foetal risk). Women should avoid becoming pregnant during treatment.International label, same formulation · electronic medicines compendium (eMC), United Kingdom
• Contraindicated during breastfeeding.International label, same formulation · electronic medicines compendium (eMC), United Kingdom

• Fludarabine phosphate: Fludarabine phosphate is dephosphorylated to 2F-ara-A, which is phosphorylated intracellularly to 2F-ara-ATP; this inhibits ribonucleotide reductase, DNA polymerases, DNA primase and DNA ligase, thereby inhibiting DNA synthesis (UK Fludara SmPC).