سعر لاستيبين 1200000 وحدة دولية فيال 1,200,000 وحدة دولية 2022

Lastipen benzathine benzylpenicillin 1,200,000 IU vial for intramuscular injection (Misr, Egypt); long-acting depot penicillin.

• Mild to moderate upper respiratory infections due to susceptible streptococci (group A), venereal infections (syphilis, yaws, bejel, pinta) and prophylaxis of rheumatic fever and/or chorea and glomerulonephritis.Population: Adults and paediatric patientsDailyMed (U.S. National Library of Medicine)

• Hypersensitivity reactions (urticaria, rash, anaphylaxis), Jarisch-Herxheimer reaction in syphilis, injection-site reactions; SJS and DRESS reported post-marketing.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• History of a previous hypersensitivity reaction to any penicillin.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Boxed warning: not for intravenous use; inadvertent IV administration has been associated with cardiorespiratory arrest and death.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Serious and occasionally fatal anaphylactic reactions (more likely with penicillin or multiple-allergen sensitivity); injection into or near a nerve or artery can cause permanent neurological damage, gangrene or necrosis.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• TetracyclineMay antagonise the bactericidal effect of penicillin; avoid concurrent use.DailyMed (U.S. National Library of Medicine)
• ProbenecidIncreases and prolongs serum penicillin levels by inhibiting renal tubular secretion.DailyMed (U.S. National Library of Medicine)

• Animal reproduction studies showed no harm to the fetus and human experience with penicillins has not shown adverse fetal effects, but no adequate controlled studies exist; use in pregnancy only if clearly needed.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Soluble penicillin G is excreted in breast milk; use with caution in nursing women.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Benzathine benzylpenicillin: Slowly hydrolysed to penicillin G, which is bactericidal by inhibiting bacterial cell-wall peptidoglycan synthesis; gives low, very prolonged serum levels.