سعر ليبراكس 30 قرص 2024

Fixed combination of chlordiazepoxide (a benzodiazepine) and clidinium bromide (an anticholinergic antispasmodic) in sugar-coated tablets (30 tablets), Eipico under licence from ICN, used for functional bowel disorders such as spastic colon.

• To control emotional and somatic factors in gastrointestinal disorders; adjunctive therapy in peptic ulcer and in irritable bowel syndrome (irritable colon, spastic colon, mucous colitis) and acute enterocolitis.Population: AdultsDailyMed (U.S. National Library of Medicine)

• Drowsiness, ataxia and confusion (particularly in elderly and debilitated patients); occasionally syncope; isolated skin eruptions, oedema, minor menstrual irregularities, nausea, constipation, extrapyramidal symptoms and changes in libido.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Anticholinergic effects typical of clidinium: dry mouth, blurred vision, urinary hesitancy and constipation. Blood dyscrasias (including agranulocytosis), jaundice and hepatic dysfunction have occasionally been reported with chlordiazepoxide.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Glaucoma (anticholinergic mydriasis), prostatic hypertrophy and benign bladder neck obstruction.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Known hypersensitivity to chlordiazepoxide hydrochloride and/or clidinium bromide.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Boxed warning: concomitant use of benzodiazepines and opioids may cause profound sedation, respiratory depression, coma and death; reserve for patients without alternatives and limit dose and duration.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Boxed warning: the benzodiazepine component exposes users to abuse, misuse and addiction, which can lead to overdose or death; assess risk before and during treatment.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Boxed warning: continued use may cause physical dependence; abrupt discontinuation or rapid dose reduction may cause life-threatening withdrawal reactions (e.g. seizures); taper gradually.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• OpioidsIncreased risk of respiratory depression and sedation; limit dose and duration of concomitant use and monitor closely.DailyMed (U.S. National Library of Medicine)
• Oral anticoagulantsVariable effects on blood coagulation have been reported very rarely with chlordiazepoxide; a causal relationship is not established.DailyMed (U.S. National Library of Medicine)
• Other psychotropic drugs (e.g. MAO inhibitors, phenothiazines)Concomitant use is generally not recommended because of possible potentiation.DailyMed (U.S. National Library of Medicine)

• Observational data do not show a clear association between benzodiazepines and major birth defects; no published data on oral clidinium in pregnancy report a drug-associated risk.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

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