سعر ليبتيتام اكس ار 500مجم 20 قرص 2024

Levetiracetam 500 mg extended-release film-coated tablets, 20 per pack (Liptitam XR, Organopharma, Egypt); antiepileptic.

• Treatment of partial-onset seizures in patients 12 years of age and older (US label for extended-release tablets).Population: Patients 12 years and olderDailyMed (U.S. National Library of Medicine)

• Most common adverse reactions with the extended-release tablets (incidence at least 5% more than placebo): somnolence and irritability.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Hypersensitivity to levetiracetam; anaphylaxis and angioedema have occurred.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Behavioural abnormalities and psychotic symptoms, suicidal behaviour and ideation, somnolence and fatigue, coordination difficulties, serious dermatological reactions (SJS/TEN) and DRESS/multiorgan hypersensitivity; discontinue at the first sign of rash unless clearly not drug-related.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Withdraw gradually to reduce the risk of increased seizure frequency and status epilepticus; patients should not drive or operate machinery until they know how the medicine affects them.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Prolonged experience in pregnant women has not identified a drug-associated risk of major birth defects or miscarriage; animal studies showed developmental toxicity; a pregnancy exposure registry exists.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Levetiracetam is excreted in human milk; there are no data on effects on the breastfed infant or on milk production; weigh the benefits of breastfeeding against the mother's clinical need.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Levetiracetam: The precise mechanism of the antiepileptic effect is unknown; levetiracetam binds the synaptic vesicle protein SV2A, which is thought to be involved in regulating vesicle exocytosis, and binding affinity correlated with antiseizure potency in animal models.