سعر مالاركوين 250مجم 20 قرص 2022

Malarquine chloroquine phosphate 250 mg tablets, 20 tablets (2 strips), antimalarial and amebicide by El Nasr (Egypt).

• Treatment of uncomplicated malaria due to susceptible strains of P. falciparum, P. malariae, P. ovale and P. vivaxPopulation: Adults and childrenDailyMed (U.S. National Library of Medicine)
• Prophylaxis of malaria in geographic areas where chloroquine resistance is not presentPopulation: Adults and childrenDailyMed (U.S. National Library of Medicine)
• Treatment of extraintestinal amebiasisPopulation: AdultsDailyMed (U.S. National Library of Medicine)

• Post-approval reactions include ocular disorders (maculopathy, irreversible retinopathy, visual disturbances, corneal opacities), urticaria/anaphylaxis, nerve-type deafness and tinnitus, myopathy/neuromyopathy, and other reactions listed in the label.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Use for indications other than acute malaria is contraindicated in the presence of retinal or visual field changes of any aetiology.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Known hypersensitivity to 4-aminoquinoline compounds.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Not effective against chloroquine- or hydroxychloroquine-resistant Plasmodium; resistance is widespread in P. falciparum and reported in P. vivax; do not use for complicated malaria.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Cardiomyopathy and QT prolongation: fatal and life-threatening cardiotoxicity (cardiomyopathy, conduction disorders, QT prolongation, torsades de pointes, ventricular arrhythmias) has been reported; risk is greater at high doses.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Severe, potentially life-threatening hypoglycaemia can occur with or without antidiabetic drugs; check blood glucose if symptoms occur.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Antacids and kaolinAntacids and kaolin can reduce chloroquine absorption; separate intake by at least 4 hours.DailyMed (U.S. National Library of Medicine)
• CimetidineCimetidine can inhibit chloroquine metabolism and increase its plasma level; avoid concomitant use.DailyMed (U.S. National Library of Medicine)
• Insulin and other antidiabetic drugsChloroquine may enhance hypoglycaemic treatment; antidiabetic doses may need to be reduced.DailyMed (U.S. National Library of Medicine)

• At recommended malaria doses, observational studies and a meta-analysis have shown no increase in the rate of birth defects or spontaneous abortions with chloroquine exposure during pregnancy; review the individual benefit-risk balance before prescribing in pregnant women.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Chloroquine is excreted in breast milk (infant dose about 0.7% of the maternal start dose); decide whether to discontinue nursing or the drug; separate chemoprophylaxis for the infant is required.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Chloroquine phosphate: 4-Aminoquinoline anti-protozoal; precise mechanism unknown - may act against Plasmodium by concentrating in the parasite's acid vesicles and inhibiting haem polymerisation; active against erythrocytic forms (US label).