سعر ميديفينتيل 100 مكجم/جرعة بخاخ أنف (8 جرعات) 2026

Fentanyl nasal spray delivering 100 micrograms per metered dose, 8 doses per bottle; strong opioid analgesic; MDI Pharma, Egypt.

• Management of breakthrough pain in cancer patients 18 years and older who are already receiving and tolerant to around-the-clock opioid therapy for underlying persistent cancer pain.Population: Opioid-tolerant adults 18 years and olderDailyMed (U.S. National Library of Medicine)

• Most common adverse reactions (5% or more): vomiting, nausea, dizziness, pyrexia and constipation.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Opioid non-tolerant patients (risk of fatal respiratory depression). Opioid-tolerant means taking for one week or longer at least 60 mg oral morphine/day, 25 mcg transdermal fentanyl/hour, 30 mg oral oxycodone/day, 8 mg oral hydromorphone/day, 25 mg oral oxymorphone/day, 60 mg oral hydrocodone/day or an equianalgesic dose of another opioid.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Management of acute or postoperative pain, including headache or migraine.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Significant respiratory depression, acute or severe bronchial asthma in an unmonitored setting, known or suspected gastrointestinal obstruction including paralytic ileus, and hypersensitivity to fentanyl.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Boxed warning: life-threatening respiratory depression, including in opioid non-tolerant patients and with improper dosing.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Boxed warning: accidental exposure to even one dose, especially in children, can result in fatal overdose; store securely out of reach of children.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Boxed warning: concomitant use with benzodiazepines or other CNS depressants, including alcohol, may cause profound sedation, respiratory depression, coma and death.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• CYP3A4 inhibitors (or discontinuation of CYP3A4 inducers)Can increase fentanyl plasma concentrations and cause fatal overdose; monitor closely and consider dose reduction.DailyMed (U.S. National Library of Medicine)
• Benzodiazepines and other CNS depressantsProfound sedation, respiratory depression, coma and death; reserve co-prescription for patients without alternatives.DailyMed (U.S. National Library of Medicine)
• Vasoconstrictive nasal decongestants (e.g. oxymetazoline)Lower peak fentanyl concentrations and delayed Tmax; may reduce effectiveness in patients with rhinitis using decongestants.DailyMed (U.S. National Library of Medicine)

• Prolonged use during pregnancy can result in neonatal opioid withdrawal syndrome, which may be life-threatening if not recognised and treated.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Breastfeeding is not recommended during treatment because of the risk of excess sedation and respiratory depression in the infant.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

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