سعر ميتوجرين 20 قرص 2022

Metograine tablets, 20 per pack (EVA Pharma): ergotamine tartrate 1 mg, caffeine anhydrous 50 mg, paracetamol 325 mg and metoclopramide hydrochloride 5 mg per tablet, an antimigraine combination.

• Ergotamine: co-administration with potent CYP3A4 inhibitors (ritonavir, nelfinavir, indinavir, erythromycin, clarithromycin, troleandomycin, ketoconazole, itraconazole); pregnancy (oxytocic effect).General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• Metoclopramide: history of tardive dyskinesia or dystonic reaction to metoclopramide; when stimulation of gastrointestinal motility might be dangerous (haemorrhage, obstruction, perforation); pheochromocytoma or catecholamine-releasing paragangliomas; epilepsy.General active-ingredient information · DailyMed (U.S. National Library of Medicine)

• Ergotamine (boxed warning, US ergotamine/caffeine tablets): serious and/or life-threatening peripheral ischaemia has occurred with co-administration of potent CYP3A4 inhibitors (protease inhibitors, macrolide antibiotics); concomitant use is contraindicated.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• Ergotamine: vasoconstrictive complications (ischaemia, cyanosis, absent pulse, cold extremities, gangrene, precordial pain) may occur; fibrotic complications (retroperitoneal, pleuropulmonary, cardiac valve) have been reported with long-term use, so it should not be used for chronic daily administration.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• Metoclopramide (boxed warning): can cause tardive dyskinesia, a potentially irreversible movement disorder, with risk increasing with duration and cumulative dose; contraindicated in patients with a history of tardive dyskinesia; use for the shortest duration.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• Paracetamol (acetaminophen): severe liver damage may occur if an adult takes more than 4,000 mg in 24 hours, takes it with other paracetamol-containing drugs, or drinks 3 or more alcoholic drinks daily; may cause severe skin reactions.General active-ingredient information · DailyMed (U.S. National Library of Medicine)

• Potent CYP3A4 inhibitors (protease inhibitors, macrolide antibiotics, azole antifungals)Raise ergotamine levels and the risk of vasospasm leading to cerebral or peripheral ischaemia; contraindicated.DailyMed (U.S. National Library of Medicine)

• Ergotamine/caffeine: contraindicated in pregnancy because of the oxytocic effects of ergotamine (historical US pregnancy category X).General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• Ergotamine is excreted in breast milk and may cause vomiting, diarrhoea, weak pulse and unstable blood pressure in nursing infants.General active-ingredient information · DailyMed (U.S. National Library of Medicine)

• Ergotamine tartrate: Alpha-adrenergic blocking agent with a direct stimulating effect on the smooth muscle of peripheral and cranial blood vessels and serotonin-antagonist properties (US label). PubChem values refer to ergotamine base.
• Caffeine (anhydrous): Also a cranial vasoconstrictor, added to ergotamine to enhance the vasoconstrictive effect without increasing the ergotamine dose (US ergotamine/caffeine label).
• Paracetamol (acetaminophen):
• Metoclopramide hydrochloride: Stimulates motility of the upper gastrointestinal tract without stimulating gastric, biliary or pancreatic secretions; increases gastric tone and contractions and relaxes the pyloric sphincter (US label). PubChem values refer to metoclopramide base.