سعر ميكتونورم 15مجم 28 اقراص 2022

Propiverine hydrochloride 15 mg sugar-coated tablets (Apogepha, Germany) for overactive bladder and urinary incontinence; pack of 28.

• Symptomatic treatment of urinary incontinence and/or increased urinary frequency and urgency in overactive bladder syndrome or neurogenic detrusor overactivity from spinal cord injuries.Population: AdultsHealth Products Regulatory Authority (HPRA), Ireland

• Very common: dry mouth. Common: headache, accommodation disorder, visual impairment, constipation, abdominal pain, dyspepsia, fatigue. Liver enzymes should be monitored during long-term therapy.International label, same formulation · Health Products Regulatory Authority (HPRA), Ireland

• Hypersensitivity; bowel obstruction; significant bladder outflow obstruction where urinary retention may be anticipated; myasthenia gravis; intestinal atony; severe ulcerative colitis; toxic megacolon; uncontrolled angle-closure glaucoma; moderate or severe hepatic impairment; tachyarrhythmias.International label, same formulation · Health Products Regulatory Authority (HPRA), Ireland

• Use with caution in autonomic neuropathy and renal or hepatic impairment; may aggravate severe heart failure, prostatic enlargement, hiatus hernia with reflux oesophagitis, arrhythmia and tachycardia; may precipitate acute angle-closure glaucoma; exclude renal, cardiac and organic bladder causes of frequency before treatment.International label, same formulation · Health Products Regulatory Authority (HPRA), Ireland
• May cause drowsiness and blurred vision, which can impair driving and use of machines.International label, same formulation · Health Products Regulatory Authority (HPRA), Ireland

• Tricyclic antidepressants, benzodiazepines, systemic anticholinergics, amantadine, neuroleptics, beta-agonistsEffects increased when combined with these drugs.Health Products Regulatory Authority (HPRA), Ireland
• Cholinergic drugsEffects of propiverine decreased.Health Products Regulatory Authority (HPRA), Ireland
• IsoniazidReduced blood pressure in patients treated with isoniazid.Health Products Regulatory Authority (HPRA), Ireland

• No data in pregnant women; animal studies showed reproductive toxicity; not recommended during pregnancy.International label, same formulation · Health Products Regulatory Authority (HPRA), Ireland
• Unknown whether excreted in human milk (excreted in animal milk); a decision is needed whether to stop breastfeeding or the medicine.International label, same formulation · Health Products Regulatory Authority (HPRA), Ireland

• Propiverine hydrochloride: Inhibits calcium influx and modulates intracellular calcium in bladder smooth muscle and blocks muscarinic receptors, relaxing the detrusor (Irish Detrunorm SmPC, section 5.1).