سعر مونوزايد 10/12.5 مجم 10 أقراص 2022

Fosinopril 10 mg with hydrochlorothiazide 12.5 mg tablets, box of 10 (Monozide, SmithKline Beecham).

• Treatment of hypertension in patients for whom combination ACE-inhibitor and thiazide therapy is appropriate (not usually for initial therapy unless clinically justified).Population: Adults with hypertensionDailyMed (US National Library of Medicine)

• Dizziness, headache, cough, fatigue, orthostatic hypotension, electrolyte changes, and rash may occur; angioedema is serious though uncommon.International label, equivalent formulation · DailyMed (US National Library of Medicine)

• Anuria; hypersensitivity to fosinopril, other ACE inhibitors, hydrochlorothiazide or sulfonamide-derived drugs; history of angioedema with ACE inhibitors; concomitant aliskiren in diabetes as labelled.International label, equivalent formulation · DailyMed (US National Library of Medicine)

• Fetal toxicity boxed warning for drugs acting on the renin-angiotensin system. Risk of hypotension, electrolyte imbalance (including hypokalaemia/hyperkalaemia), renal impairment, angioedema, and sulfonamide-related idiosyncratic reactions with the thiazide component.International label, equivalent formulation · DailyMed (US National Library of Medicine)

• Discontinue when pregnancy is detected because of fetal toxicity of ACE inhibitors; thiazides cross the placenta.International label, equivalent formulation · DailyMed (US National Library of Medicine)

• Fosinopril: Prodrug converted to fosinoprilat, which inhibits ACE, reducing angiotensin II formation and aldosterone secretion, leading to vasodilation and lower blood pressure.
• Hydrochlorothiazide: Promotes renal excretion of sodium and chloride, reducing intravascular volume.