سعر ناراتريبتان 2.5مجم 2 قرص 2025

Naratriptan 2.5 mg 2 f.c. tabs (Chanelle Pharmaceuticals > Diligence Pharma, Egypt): naratriptan 2.5 mg film-coated tablets, a selective 5-HT1B/1D receptor agonist (triptan) for acute migraine.

• Acute treatment of migraine with or without auraPopulation: AdultsDailyMed (U.S. National Library of Medicine)

• Most common (>=2% and above placebo): paraesthesia, nausea, dizziness, drowsiness, malaise/fatigue and throat/neck symptoms.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Ischaemic coronary artery disease or coronary vasospasm (incl. Prinzmetal angina); Wolff-Parkinson-White or other accessory-pathway arrhythmias; history of stroke, TIA, hemiplegic or basilar migraine; peripheral vascular disease; ischaemic bowel disease; uncontrolled hypertension; another 5-HT1 agonist or ergot-type drug within 24 hours; hypersensitivity; severe renal or hepatic impairment.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Myocardial ischaemia/infarction and Prinzmetal angina: evaluate cardiovascular risk before first use in patients with multiple risk factors; discontinue if arrhythmia, cerebrovascular event, GI ischaemia or peripheral vasospasm occurs.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Medication-overuse headache (detoxification may be needed) and serotonin syndrome (especially with SSRIs, SNRIs, TCAs or MAOIs); blood pressure increases and hypersensitivity reactions (anaphylaxis, angioedema) reported.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Ergot-containing drugs (ergotamine, dihydroergotamine, methysergide)Use within 24 hours of naratriptan is contraindicated (additive prolonged vasospasm).DailyMed (U.S. National Library of Medicine)
• Other 5-HT1B/1D agonists (triptans)Use within 24 hours is contraindicated (additive vasospastic risk).DailyMed (U.S. National Library of Medicine)
• SSRIs, SNRIs, tricyclic antidepressants, MAO inhibitorsSerotonin syndrome has been reported with triptans; discontinue if suspected.DailyMed (U.S. National Library of Medicine)

• No adequate data on developmental risk in pregnancy; registry data too small for conclusions; animal studies showed embryolethality and fetal abnormalities at exposures 2.5-11 times human exposure.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• No data on presence in human milk; naratriptan is present in rat milk; weigh benefits of breastfeeding against maternal need.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Naratriptan: Binds 5-HT1B/1D receptors on intracranial vessels and trigeminal sensory nerves, causing cranial vessel constriction and inhibiting pro-inflammatory neuropeptide release (US label).