سعر نيبراس 60مجم 5 امبول 2022

Nipruss 60 mg sodium nitroprusside dihydrate lyophilisate for IV infusion, 5 ampoules (Schwarz > AMC).

• Treatment of hypertensive crises in adults; controlled hypotension during surgery in adults. Not for long-term therapy.Population: AdultsRote Liste / Fachinfo (Germany)

• Excessive hypotension, reflex tachycardia, headache, nausea; cyanide toxicity signs (bright venous blood, metabolic acidosis, lactate rise, arrhythmias, seizures, coma); thiocyanate toxicity (weakness, vomiting, tinnitus, psychosis) with prolonged use.International label, same product · Rote Liste / Fachinfo (Germany)

• Hypersensitivity to sodium nitroprusside.International label, same product · Rote Liste / Fachinfo (Germany)
• Compensatory hypertension (e.g. aortic coarctation or arteriovenous shunts); Leber optic atrophy; tobacco amblyopia; vitamin B12 deficiency; metabolic acidosis; hypothyroidism; intrapulmonary AV shunts.International label, same product · Rote Liste / Fachinfo (Germany)

• US boxed warning (equivalent parenteral SNP): not for direct injection — must be diluted in sterile 5% dextrose; can cause precipitous BP drops leading to irreversible ischemic injury or death if not continuously monitored.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Cyanide and thiocyanate toxicity risk, especially with prolonged/high-dose infusions or renal/hepatic impairment; monitor thiocyanate (keep ≤6 mg/100 ml); co-infuse thiosulfate; have cyanide antidotes available.International label, same product · Rote Liste / Fachinfo (Germany)
• Use caution if PDE-5 inhibitors were taken recently (within ~24 h of sildenafil/vardenafil or ~48 h of tadalafil) — profound hypotension possible; careful titration.International label, same product · Rote Liste / Fachinfo (Germany)

• PDE-5 inhibitors (sildenafil, tadalafil, vardenafil)MajorMarked potentiation of hypotensive effect.Rote Liste / Fachinfo (Germany)
• Other vasodilators / antihypertensives / anaesthetics / sedativesModerateAdditive blood-pressure lowering.Rote Liste / Fachinfo (Germany)

• Insufficient experience in pregnancy and lactation; German SmPC advises use only if strictly indicated.International label, same product · Rote Liste / Fachinfo (Germany)

• Sodium nitroprusside: Releases nitric oxide after IV infusion, relaxing arteriolar and venous smooth muscle.