سعر نيتروديرم تي تي اس 10مجم 7 باتش 10 مجم/24 h 2024

Nitroderm TTS 10 transdermal patches (nitroglycerin, Novartis > Sandoz), box of 7, sold in Egypt; transdermal nitrate for prevention of angina.

• Treatment of angina pectoris, alone or with beta blockers and/or calcium antagonistsPopulation: AdultsMedsafe (New Zealand Medicines and Medical Devices Safety Authority)
• Supplementary treatment of congestive heart failure not responding adequately to conventional therapyPopulation: AdultsMedsafe (New Zealand Medicines and Medical Devices Safety Authority)

• Very common: nausea, vomiting. Common: headache (dose-dependent, often regresses). Uncommon: contact dermatitis, application-site erythema, pruritus, burning, irritation. Rare: tachycardia, orthostatic hypotension, flushing. Post-marketing: palpitation, generalised rash.International label, same product · Medsafe (New Zealand Medicines and Medical Devices Safety Authority)

• Hypersensitivity to nitroglycerin, related organic nitrates or excipients; acute circulatory failure with marked hypotension (shock); conditions with elevated intracranial pressure; myocardial insufficiency due to obstruction (aortic or mitral stenosis, constrictive pericarditis); concomitant PDE5 inhibitors.International label, same product · Medsafe (New Zealand Medicines and Medical Devices Safety Authority)
• US label: allergy to nitroglycerin or to the patch adhesives; use with PDE-5 inhibitors or riociguat.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Remove the patch before MRI, cardioversion/DC defibrillation or diathermy (aluminium layer). Withdraw gradually when switching long-term therapy. Use cautiously after recent myocardial infarction or acute heart failure, in hypoxaemia, and in hypertrophic cardiomyopathy; angina may increase during patch-off periods.International label, same product · Medsafe (New Zealand Medicines and Medical Devices Safety Authority)

• PDE-5 inhibitors (sildenafil, tadalafil, vardenafil, avanafil)Contraindicated: PDE-5 inhibitors amplify the vasodilatory effect of nitrates and can cause severe hypotension, syncope or myocardial ischaemia.Medsafe (New Zealand Medicines and Medical Devices Safety Authority)
• Riociguat (soluble guanylate cyclase stimulator)Contraindicated: concomitant use can cause hypotension.DailyMed (U.S. National Library of Medicine)
• Antihypertensives, calcium antagonists, ACE inhibitors, beta-blockers, diuretics, tricyclic antidepressants, major tranquillisers, alcoholMay potentiate the blood-pressure-lowering effect.Medsafe (New Zealand Medicines and Medical Devices Safety Authority)

• Use with caution during pregnancy, especially in the first 3 months.International label, same product · Medsafe (New Zealand Medicines and Medical Devices Safety Authority)
• Unknown whether nitroglycerin passes into breast milk; weigh benefit to the mother against risk to the child.International label, same product · Medsafe (New Zealand Medicines and Medical Devices Safety Authority)

• Nitroglycerin (glyceryl trinitrate): Nitroglycerin forms nitric oxide, which activates guanylate cyclase and raises cyclic GMP in vascular smooth muscle, causing vasodilatation (venous more than arterial) (US Nitrolingual label 12.1).