سعر انجيلو 10 مجم 30 قرص 2024

Oral tablets containing nicorandil 10 mg, a potassium-channel-opening antianginal (Angilow, Adwia/Tabuk, Egypt); 30 tablets per pack.

• Symptomatic treatment of stable angina pectoris in adults inadequately controlled by, or with a contraindication or intolerance to, first-line antianginal therapies (beta-blockers and/or calcium antagonists)Population: Adultselectronic medicines compendium (emc), UK

• Very common: headache (particularly at treatment start, usually transient). Common: dizziness, flushing, nausea, vomiting, weakness, increased heart rate.International label, same formulation · electronic medicines compendium (emc), UK
• Other reported: GI, skin, mucosal and eye ulcerations, hyperkalaemia, angioedema, hypotension, rash, hepatic disorders.International label, same formulation · electronic medicines compendium (emc), UK

• Hypersensitivity to nicorandil or any excipient.International label, same formulation · electronic medicines compendium (emc), UK
• Shock (including cardiogenic shock), severe hypotension, left ventricular dysfunction with low filling pressure or cardiac decompensation.International label, same formulation · electronic medicines compendium (emc), UK
• Concomitant PDE-5 inhibitors or soluble guanylate cyclase stimulators (riociguat).International label, same formulation · electronic medicines compendium (emc), UK

• Gastrointestinal (including oral, anal, intestinal), skin, mucosal and eye ulcerations may occur, some with perforation, fistula or abscess; discontinue nicorandil if ulceration develops.International label, same formulation · electronic medicines compendium (emc), UK
• Increased risk of GI haemorrhage with aspirin or NSAIDs, and of GI perforation with corticosteroids.International label, same formulation · electronic medicines compendium (emc), UK
• Hypotension; caution in heart failure NYHA class III-IV; hyperkalaemia (especially with renal impairment or potassium-raising drugs); avoid in G6PD deficiency.International label, same formulation · electronic medicines compendium (emc), UK

• PDE-5 inhibitors (sildenafil, tadalafil, vardenafil) and riociguatSerious hypotension - contraindicated.electronic medicines compendium (emc), UK
• Aspirin / NSAIDsIncreased risk of serious complications such as GI ulceration, perforation and haemorrhage.electronic medicines compendium (emc), UK
• CorticosteroidsGI perforation reported with concomitant use; caution.electronic medicines compendium (emc), UK

• No adequate human data; animal studies showed no harm. As a precaution, avoid use during pregnancy.International label, same formulation · electronic medicines compendium (emc), UK
• Excretion in human milk is unknown; not recommended during breastfeeding.International label, same formulation · electronic medicines compendium (emc), UK

• Nicorandil: Dual action: opens ATP-sensitive potassium channels (arterial vasodilation, reduced afterload) and, through its nitrate moiety, increases cyclic GMP (venous relaxation, reduced preload); also dilates coronary arteries.