سعر نورمونات 30مجم 7 اقراص 2023

Tolvaptan 30 mg tablets, pack of 7 (Marcyrl, Egypt); selective vasopressin V2-receptor antagonist for hypervolaemic/euvolaemic hyponatraemia.

• Clinically significant hypervolaemic and euvolaemic hyponatraemia (serum sodium <125 mEq/L, or less marked symptomatic hyponatraemia resistant to fluid restriction), including patients with heart failure and SIADH.Population: AdultsDailyMed (U.S. National Library of Medicine)

• Most common (>=5% over placebo): thirst, dry mouth, asthenia, constipation, pollakiuria or polyuria, and hyperglycaemia.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• ADPKD outside the FDA-approved REMS; inability to sense or respond to thirst; hypovolaemic hyponatraemia; concomitant strong CYP3A inhibitors; anuria; hypersensitivity to tolvaptan or components.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Boxed warning: too rapid correction of hyponatraemia (e.g. >12 mEq/L/24 h) can cause osmotic demyelination (dysarthria, mutism, dysphagia, lethargy, spastic quadriparesis, seizures, coma, death); slower correction may be advisable in malnutrition, alcoholism or advanced liver disease.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Boxed warning: not for use in autosomal dominant polycystic kidney disease (ADPKD) outside the FDA-approved REMS because of the risk of hepatotoxicity.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Strong CYP3A inhibitorsConcomitant use with strong CYP3A inhibitors is contraindicated.DailyMed (U.S. National Library of Medicine)

• Human data insufficient to determine drug-associated risk; embryo-fetal effects (including malformations in rabbits) occurred in animals at maternally toxic doses.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• No human milk data; tolvaptan is present in rat milk. Advise women not to breastfeed during treatment (risk of electrolyte abnormalities, hypotension and volume depletion in the infant).International label, same formulation · DailyMed (U.S. National Library of Medicine)

English text not available for this section.