سعر اولانزا 5مجم 30 قرص 2022

Olanza: olanzapine 5 mg film-coated tablets, pack of 20 (EVA Pharma, Egypt). Atypical antipsychotic.

• Schizophrenia.Population: Adults and adolescents 13-17 yearsDailyMed (U.S. National Library of Medicine)
• Bipolar I disorder (manic or mixed episodes): acute monotherapy and maintenance monotherapy, and adjunct to lithium or valproate for acute treatment.Population: Adults (monotherapy also adolescents 13-17 years)DailyMed (U.S. National Library of Medicine)
• In combination with fluoxetine: depressive episodes of bipolar I disorder and treatment-resistant depression (olanzapine monotherapy is not indicated for these).Population: Adults (bipolar depression also children 10-17 years)DailyMed (U.S. National Library of Medicine)

• Most common (at least 5% and twice placebo) in adult schizophrenia: postural hypotension, constipation, weight gain, dizziness, personality disorder, akathisia. In adult bipolar mania monotherapy: asthenia, dry mouth, constipation, increased appetite, somnolence, dizziness, tremor.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• None for olanzapine monotherapy (when used with fluoxetine, lithium or valproate, refer to the contraindications of those medicines).International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Boxed warning: elderly patients with dementia-related psychosis treated with antipsychotics are at increased risk of death; olanzapine is not approved for dementia-related psychosis.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Neuroleptic malignant syndrome; drug reaction with eosinophilia and systemic symptoms (DRESS); metabolic changes (hyperglycaemia, diabetes, dyslipidaemia, weight gain); tardive dyskinesia; orthostatic hypotension; leukopenia, neutropenia and agranulocytosis; seizures; potential for cognitive and motor impairment (somnolence); body temperature dysregulation; anticholinergic effects; hyperprolactinaemia; suicidal thoughts in bipolar disorder and schizophrenia.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Fluvoxamine (CYP1A2 inhibitor)Inhibits olanzapine elimination; consider lower olanzapine doses.DailyMed (U.S. National Library of Medicine)
• Carbamazepine, omeprazole, rifampin (CYP1A2 inducers)May increase olanzapine clearance (carbamazepine by about 50%).DailyMed (U.S. National Library of Medicine)
• Activated charcoalActivated charcoal (1 g) reduced the Cmax and AUC of oral olanzapine by about 60%.DailyMed (U.S. National Library of Medicine)

• Overall available data from published epidemiologic studies of pregnant women exposed to olanzapine have not established a drug-associated risk of major birth defects, miscarriage or adverse maternal or fetal outcomes.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Olanzapine is present in human milk; there are reports of excess sedation, irritability, poor feeding and extrapyramidal symptoms in breastfed infants. Monitor breastfed infants.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Olanzapine: The mechanism of action in the listed indications is unclear; efficacy in schizophrenia could be mediated through a combination of dopamine and serotonin type 2 (5-HT2) antagonism.