سعر بانادول اكسترا 48 قرص 2024

Panadol Extra: paracetamol plus caffeine film-coated tablets, analgesic/antipyretic for headache and other pain.

• Treatment of most painful and febrile conditions, e.g. headache including migraine, backache, toothache, rheumatic pain, dysmenorrhoea, and relief of symptoms of colds, influenza and sore throat.Population: Adults and adolescents per sourceelectronic medicines compendium (emc)

• Caffeine-related: dizziness, headache, palpitation, insomnia, restlessness, anxiety, irritability, gastrointestinal disturbances, especially with dietary caffeine.International label, equivalent formulation · electronic medicines compendium (emc)
• Paracetamol (post-marketing, very rare): thrombocytopenia, agranulocytosis, anaphylaxis, skin hypersensitivity reactions including rash and angioedema, serious skin reactions, bronchospasm (more likely in aspirin/NSAID-sensitive patients), hepatic dysfunction.International label, equivalent formulation · electronic medicines compendium (emc)

• Hypersensitivity to paracetamol, caffeine or any other constituent.International label, equivalent formulation · electronic medicines compendium (emc)

• Avoid excessive caffeine intake (coffee, tea, some canned drinks) while taking this product.International label, equivalent formulation · electronic medicines compendium (emc)
• Contains paracetamol: do not use with other paracetamol-containing products; overdose may cause liver failure requiring transplant or death. Greater hazard in non-cirrhotic alcoholic liver disease; care in hepatic or renal impairment.International label, equivalent formulation · electronic medicines compendium (emc)
• High anion gap metabolic acidosis due to pyroglutamic acidosis has been reported with prolonged therapeutic paracetamol use in severe illness, malnutrition or glutathione deficiency, or with flucloxacillin.International label, equivalent formulation · electronic medicines compendium (emc)

• LithiumCaffeine may increase lithium clearance; concomitant use not recommended.electronic medicines compendium (emc)
• Warfarin and other coumarinsProlonged regular daily paracetamol use may enhance the anticoagulant effect with increased bleeding risk; occasional doses have no significant effect.electronic medicines compendium (emc)
• Metoclopramide, domperidone, colestyramineMetoclopramide or domperidone may speed paracetamol absorption; colestyramine reduces it.electronic medicines compendium (emc)

• Not recommended in pregnancy because of possible increased risk of lower birth weight and spontaneous abortion associated with caffeine.International label, equivalent formulation · electronic medicines compendium (emc)
• Caffeine in breast milk may stimulate the breast-fed infant; the UK label advises not to use while breastfeeding.International label, equivalent formulation · electronic medicines compendium (emc)

• Paracetamol: The precise analgesic and antipyretic mechanism is not established but is thought to involve mainly central actions (US Ofirmev label).
• Caffeine: Most effects are attributed to antagonism of adenosine A1 and A2A receptors (UK caffeine citrate SmPC).