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Oral tablets combining paracetamol and caffeine for mild-to-moderate pain and headache; Egyptian El Nile product.

• Known hypersensitivity to paracetamol, caffeine or excipients; severe hepatic impairment for paracetamol-containing products.General active-ingredient information · UK eMC / MHRA

• Risk of serious liver injury with paracetamol overdose or use with other paracetamol products/alcohol. Limit caffeine intake from other sources. Seek advice in pregnancy.General active-ingredient information · UK eMC / MHRA, NIH / PubChem

• Other paracetamol-containing productsMajorAdditive paracetamol exposure increases hepatotoxicity risk; check all cold/pain remedies.UK eMC / MHRA

• Paracetamol is widely used in pregnancy at recommended doses when clinically needed; caffeine intake should be moderated in pregnancy. Product-specific Egyptian pregnancy labelling was not opened.General active-ingredient information · NIH / PubChem

• Paracetamol: The precise analgesic and antipyretic mechanism is not established but is thought to involve mainly central actions (US Ofirmev label).
• Caffeine: Most effects are attributed to antagonism of adenosine A1 and A2A receptors (UK caffeine citrate SmPC).