سعر بانادول نايت 20 قرص 2022

Panadol Night: paracetamol 500 mg with the sedating antihistamine diphenhydramine hydrochloride 25 mg, for night-time pain associated with difficulty sleeping.

• Short-term treatment of bedtime pain (e.g. rheumatic and muscle pain, backache, toothache, migraine, headache, period pain) causing difficulty in getting to sleep.Population: Adults and adolescents per sourceelectronic medicines compendium (emc)

• Diphenhydramine, common: fatigue, sedation, drowsiness, disturbance in attention, unsteadiness, dizziness, dry mouth; not known: confusion, paradoxical excitation, convulsions, blurred vision, tachycardia, urinary retention.International label, same formulation · electronic medicines compendium (emc)
• Paracetamol (post-marketing, very rare): thrombocytopenia, agranulocytosis, anaphylaxis, skin hypersensitivity reactions including rash and angioedema, serious skin reactions, bronchospasm (more likely in aspirin/NSAID-sensitive patients), hepatic dysfunction.International label, same formulation · electronic medicines compendium (emc)

• Hypersensitivity to paracetamol, diphenhydramine hydrochloride or other constituents; porphyria.International label, same formulation · electronic medicines compendium (emc)

• Avoid other antihistamine-containing products (including topical and cough/cold medicines) and alcohol; use with caution in epilepsy, myasthenia gravis, narrow-angle glaucoma, prostatic hypertrophy, urinary retention, asthma, bronchitis and COPD.International label, same formulation · electronic medicines compendium (emc)
• May cause drowsiness, dizziness, blurred vision and psychomotor impairment; do not drive or operate machinery if affected.International label, same formulation · electronic medicines compendium (emc)
• Contains paracetamol: do not use with other paracetamol-containing products; overdose may cause liver failure requiring transplant or death. Greater hazard in non-cirrhotic alcoholic liver disease; care in hepatic or renal impairment.International label, same formulation · electronic medicines compendium (emc)

• Alcohol and CNS depressantsDiphenhydramine may potentiate the sedative action of alcohol and other CNS depressants (e.g. codeine, tranquillisers, hypnotics, anxiolytics) and other antihistamines.electronic medicines compendium (emc)
• MAOIs; anticholinergics; CYP2D6 substratesMAOIs may prolong antimuscarinic effects (caution within 2 weeks of an MAOI); anticholinergic effects of atropine/tricyclics may be potentiated; diphenhydramine inhibits CYP2D6 (e.g. metoprolol, venlafaxine).electronic medicines compendium (emc)
• Warfarin and other coumarinsProlonged regular daily paracetamol use may enhance the anticoagulant effect with increased bleeding risk; occasional doses have no significant effect.electronic medicines compendium (emc)

• Should not be used in pregnancy unless the expected benefit justifies the potential risk to the foetus; sedating antihistamines in the third trimester may cause reactions in the newborn.International label, same formulation · electronic medicines compendium (emc)
• Should not be used while breastfeeding without medical advice; diphenhydramine is detected in breast milk with unknown effects on the infant.International label, same formulation · electronic medicines compendium (emc)

• Paracetamol: The precise analgesic and antipyretic mechanism is not established but is thought to involve mainly central actions (US Ofirmev label).
• Diphenhydramine hydrochloride: Competitive H1-receptor antagonism; central antitussive effects.