سعر Parkimedine 50 mg film-coated tablets 2026

Safinamide 50 mg film-coated tablets (MAO-B inhibitor), pack of 20.

• Adjunctive treatment to levodopa/carbidopa in patients with Parkinson disease experiencing "off" episodes.Population: AdultsDailyMed (US National Library of Medicine)

• Concomitant MAO inhibitors or potent MAO inhibitors (including linezolid); opioids such as meperidine, methadone, tramadol; SNRIs, tricyclic/tetracyclic/triazolopyridine antidepressants; cyclobenzaprine; methylphenidate, amphetamines; St John's wort; severe hepatic impairment.International label, same formulation · DailyMed (US National Library of Medicine)

• May cause or worsen hypertension, serotonin syndrome with interacting drugs, falling asleep during daily activities, dyskinesia, hallucinations/psychotic behaviour, impulse-control problems, withdrawal-emergent hyperpyrexia and confusion, and retinal pathology.International label, same formulation · DailyMed (US National Library of Medicine)

• MAO inhibitors including linezolidContraindicated: risk of hypertensive crisis.DailyMed (US National Library of Medicine)

• No adequate human data; developmental toxicity including teratogenic effects observed in animals at clinically relevant doses.International label, same formulation · DailyMed (US National Library of Medicine)
• No information on presence in human milk; skin discoloration from hepatobiliary toxicity seen in rat pups exposed via milk.International label, same formulation · DailyMed (US National Library of Medicine)

• Safinamide: Inhibition of MAO-B is thought to reduce dopamine catabolism and increase dopaminergic activity; the precise mechanism in Parkinson disease is unknown (US Xadago label).