سعر كارينوبا بلس 200/50/200 مجم قرص مغلف 2026

Egyptian film-coated tablet combining levodopa 200 mg, carbidopa 50 mg and entacapone 200 mg (Elixir Pharma) for Parkinson's disease with end-of-dose motor fluctuations.

• Parkinson's disease with end-of-dose motor fluctuations not stabilised on levodopa/DDC-inhibitor treatment (adults)Population: AdultsElixir Pharma (official website)
• Parkinson's disease: to substitute for carbidopa/levodopa and entacapone given separately, or to replace carbidopa/levodopa when end-of-dose wearing-off occurs (total levodopa 600 mg/day or less, no dyskinesias)Population: AdultsDailyMed (U.S. National Library of Medicine)

• Most common (incidence at least 3% above placebo): dyskinesia, hyperkinesia, diarrhoea, nausea, abdominal pain, vomiting, dry mouth and urine discoloration.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Concomitant nonselective MAO inhibitors (e.g. phenelzine, tranylcypromine), which must be stopped at least 2 weeks before starting.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Narrow-angle glaucoma.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• May cause falling asleep during daily activities and somnolence, orthostatic hypotension/syncope, dyskinesia, depression and suicidality, hallucinations/psychotic-like behaviour, impulse-control problems, diarrhoea/colitis and rhabdomyolysis; abrupt withdrawal may cause hyperpyrexia and confusion.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Evaluate vitamin B6 levels before and during treatment (deficiency-related seizures reported).International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Drugs metabolised by COMT (e.g. isoproterenol, epinephrine, norepinephrine, dopamine, dobutamine, methyldopa, apomorphine)Use with caution: increased heart rate, possible arrhythmias and excessive blood-pressure changes.DailyMed (U.S. National Library of Medicine)
• Antihypertensive agentsSymptomatic postural hypotension; antihypertensive dose adjustment may be needed.DailyMed (U.S. National Library of Medicine)
• Dopamine D2 antagonists, isoniazid, phenytoin, papaverine, iron saltsMay reduce the therapeutic effect of levodopa.DailyMed (U.S. National Library of Medicine)

• No adequate data in pregnant women; in animals, carbidopa-levodopa or entacapone was associated with developmental toxicity including fetal malformations.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Levodopa is found in human milk; no data for carbidopa or entacapone. Levodopa may inhibit lactation by lowering prolactin. Weigh benefits of breastfeeding against maternal need.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Levodopa:
• Carbidopa:
• Entacapone: Inhibits peripheral catechol-O-methyltransferase, prolonging the plasma half-life of levodopa.