سعر سافينوزول 50مجم 10 اقراص 2025

Safinozol 50 mg tablets (pack of 10) contain safinamide, a selective monoamine oxidase B (MAO-B) inhibitor used as add-on to levodopa/carbidopa in Parkinson's disease patients with "off" episodes.

• Adjunctive treatment to levodopa/carbidopa in Parkinson's disease patients experiencing "off" episodesPopulation: AdultsDailyMed (U.S. National Library of Medicine)

• Dyskinesia (21% with 50 mg, 18% with 100 mg vs 9% placebo) and hypertension (7% with 50 mg, 5% with 100 mg vs 4% placebo) were reported in clinical trials.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Concomitant use of other MAO inhibitors or potent MAO inhibitors such as linezolid (risk of hypertensive crisis).International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Concomitant opioids (e.g. meperidine and derivatives, methadone, propoxyphene, tramadol), SNRIs, tricyclic/tetracyclic/triazolopyridine antidepressants, cyclobenzaprine, methylphenidate, amphetamine and derivatives, or St John's wort (risk of life-threatening serotonin syndrome); concomitant dextromethorphan.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Severe hepatic impairment (Child-Pugh C).International label, same formulation · DailyMed (U.S. National Library of Medicine)

• May cause or worsen hypertension; monitor blood pressure, especially with sympathomimetics such as nasal/oral/ophthalmic decongestants; do not exceed recommended doses because MAO-B selectivity decreases above them.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Serotonin syndrome risk; use the lowest effective dose of SSRIs with safinamide.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Falling asleep during activities of daily living (including driving), dyskinesia, hallucinations/psychotic behaviour, impulse-control/compulsive behaviours, and withdrawal-emergent hyperpyrexia and confusion on rapid dose reduction may occur.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Dopamine antagonists (antipsychotics, metoclopramide)May decrease the effectiveness of safinamide and exacerbate Parkinson's disease symptoms.DailyMed (U.S. National Library of Medicine)
• Tyramine-rich foodsAvoid foods containing large amounts of tyramine (aged cheese, pickled herring, cured/fermented foods) because of the risk of severe hypertension.DailyMed (U.S. National Library of Medicine)
• IsoniazidHas some MAO-inhibiting activity; monitor for hypertension and dietary tyramine reaction.DailyMed (U.S. National Library of Medicine)

• No adequate data in pregnant women; developmental toxicity including teratogenic effects was seen in animals at clinically relevant doses (and at lower doses when combined with levodopa/carbidopa); based on animal data, may cause fetal harm.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• No information on presence in human milk or effects on the breastfed infant; skin discoloration from hepatobiliary toxicity was seen in rat pups exposed through milk. Weigh benefits of breastfeeding against maternal need and potential infant risk.International label, same formulation · DailyMed (U.S. National Library of Medicine)

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