سعر بنتاستاتين 20 مجم 28 قرص 2024

Rosuvastatin 20 mg film-coated tablets (Pentastatin, Penta Pharma Egypt), an HMG-CoA reductase inhibitor (statin) lipid-lowering agent; box of 28 tablets.

• Reduction of LDL-C as an adjunct to diet and exercise in adults with hypercholesterolaemiaPopulation: AdultsDailyMed (U.S. National Library of Medicine)
• Reduction of the risk of major adverse cardiovascular events in adults at increased riskPopulation: AdultsDailyMed (U.S. National Library of Medicine)

• Most frequent adverse reactions (rate 2% or more): headache, nausea, myalgia, asthenia and constipation.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Acute liver failure or decompensated cirrhosis.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Hypersensitivity to rosuvastatin or any excipient (rash, pruritus, urticaria, angioedema reported).International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Myopathy and rhabdomyolysis: risk factors include age 65 years or older, uncontrolled hypothyroidism, renal impairment, certain concomitant drugs, higher dosage and Asian ancestry; discontinue if CK is markedly elevated or myopathy is suspected.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Hepatic dysfunction: transaminase increases reported; consider liver enzyme testing before starting and as clinically indicated; stop if serious hepatic injury occurs.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Immune-mediated necrotizing myopathy, proteinuria/haematuria and increases in HbA1c and fasting glucose have been reported.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Aluminium and magnesium hydroxide antacidsReduce rosuvastatin exposure; give rosuvastatin at least 2 hours before the antacid.DailyMed (U.S. National Library of Medicine)
• Other lipid-lowering therapies and certain other drugsIncrease the risk of myopathy and rhabdomyolysis; dosage modifications or avoidance recommended per label.DailyMed (U.S. National Library of Medicine)

• Discontinue when pregnancy is recognised (or consider ongoing therapeutic needs); may cause fetal harm based on mechanism; observational data with statins have not identified a drug-associated risk of major congenital malformations.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Present in human milk; breastfeeding is not recommended during treatment.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Rosuvastatin: Inhibits HMG-CoA reductase, the rate-limiting enzyme of cholesterol synthesis, lowering hepatic cholesterol and LDL-C.