سعر بيراكتام 1.5جم فيال 2025

Cefoperazone 1 g + sulbactam 0.5 g (2:1) powder for injection vial, a third-generation cephalosporin with a beta-lactamase inhibitor.

• Infections caused by susceptible organisms: upper and lower respiratory tract, upper and lower urinary tract, peritonitis/cholecystitis/cholangitis and other intra-abdominal infections, septicemia, meningitis, skin and soft tissue, bone and joint, and genital tract infections (PID, endometritis, gonorrhoea).Population: Adults and childrenPfizer Labeling (labeling.pfizer.com)

• Very common: neutropenia, leucopenia, positive Coombs test, decreased haemoglobin/haematocrit, thrombocytopenia, raised ALT/AST/alkaline phosphatase. Common: diarrhoea, nausea, vomiting, eosinophilia, coagulopathy, raised bilirubin. Uncommon: headache, pruritus, urticaria, infusion-site phlebitis, injection-site pain, fever, chills.International label, same formulation · Pfizer Labeling (labeling.pfizer.com)

• Hypersensitivity to sulbactam, cefoperazone, beta-lactams or any excipient.International label, same formulation · Pfizer Labeling (labeling.pfizer.com)

• Serious, sometimes fatal anaphylaxis and severe skin reactions (TEN, SJS, exfoliative dermatitis) have been reported.International label, same formulation · Pfizer Labeling (labeling.pfizer.com)
• Haemorrhage (sometimes fatal) and vitamin K deficiency coagulopathy; monitor PT/INR in at-risk patients and those on oral anticoagulants and give vitamin K as indicated.International label, same formulation · Pfizer Labeling (labeling.pfizer.com)
• Clostridioides difficile-associated diarrhea and superinfection with non-susceptible organisms may occur.International label, same formulation · Pfizer Labeling (labeling.pfizer.com)

• AlcoholFlushing, sweating, headache and tachycardia reported when alcohol taken during and up to the fifth day after cefoperazone; avoid ethanol-containing feeding solutions.Pfizer Labeling (labeling.pfizer.com)
• AminoglycosidesPhysically incompatible if mixed; give sequentially with separate tubing and monitor renal function.Pfizer Labeling (labeling.pfizer.com)
• Benedict's / Fehling's urine glucose testsFalse-positive urine glucose reaction may occur.Pfizer Labeling (labeling.pfizer.com)

• Rat studies up to 10 times the human dose showed no teratogenicity; both components cross the placenta; no adequate human studies, use only if clearly needed.International label, same formulation · Pfizer Labeling (labeling.pfizer.com)
• Only small quantities of both drugs are excreted in breast milk; use with caution in nursing mothers.International label, same formulation · Pfizer Labeling (labeling.pfizer.com)

• Cefoperazone: Third-generation cephalosporin that inhibits bacterial cell-wall mucopeptide synthesis (SULPERAZON document).
• Sulbactam: Irreversible inhibitor of most important beta-lactamases, protecting cefoperazone from destruction by resistant organisms (SULPERAZON document).