سعر سولبيرازون 1.5جم امبول عضل/وريد 2022

Sulbactam/cefoperazone 1.5 g (0.5 g sulbactam + 1 g cefoperazone, 1:2) powder for IV/IM injection, 1 vial; third-generation cephalosporin with beta-lactamase inhibitor.

• Respiratory, urinary, intra-abdominal, skin/soft tissue, bone/joint and genital tract infections, septicaemia and meningitis caused by susceptible organismsPopulation: Adults and childrenPfizer Labeling (labeling.pfizer.com)

• Hypersensitivity to sulbactam, cefoperazone, beta-lactams or any excipient.International label, same formulation · Pfizer Labeling (labeling.pfizer.com)

• Serious, occasionally fatal anaphylaxis and severe skin reactions (TEN, SJS, exfoliative dermatitis) reported; ask about prior beta-lactam allergy.International label, same formulation · Pfizer Labeling (labeling.pfizer.com)
• Haemorrhage (sometimes fatal) and vitamin K deficiency with coagulopathy reported; monitor PT/INR in at-risk patients and those on oral anticoagulants; give vitamin K as indicated.International label, same formulation · Pfizer Labeling (labeling.pfizer.com)
• Clostridioides difficile-associated diarrhoea may occur, up to two months after treatment.International label, same formulation · Pfizer Labeling (labeling.pfizer.com)

• AlcoholDisulfiram-like reaction (flushing, sweating, headache, tachycardia) reported with alcohol during and up to the fifth day after cefoperazone; avoid ethanol-containing feeding solutions.Pfizer Labeling (labeling.pfizer.com)
• AminoglycosidesIf combined with an aminoglycoside, monitor renal function.Pfizer Labeling (labeling.pfizer.com)

• Animal studies showed no teratogenicity; both drugs cross the placenta; no adequate human studies - use in pregnancy only if clearly needed.International label, same formulation · Pfizer Labeling (labeling.pfizer.com)
• Only small quantities are excreted in human milk; use with caution in nursing mothers.International label, same formulation · Pfizer Labeling (labeling.pfizer.com)

• Cefoperazone: Broad-spectrum cephalosporin inhibiting bacterial cell-wall synthesis; extensively excreted in bile.
• Sulbactam: Irreversible beta-lactamase inhibitor (penicillanic acid sulfone) protecting cefoperazone from hydrolysis.