سعر ريجيلا 1.5مجم 28 كبسولة 2026

Cariprazine 1.5 mg hard capsules, an atypical antipsychotic for schizophrenia in adults; 28 capsules (4 strips), Gedeon Richter, distributed by Hikma Pharma.

• Schizophrenia in adult patientsPopulation: Adultselectronic medicines compendium (eMC)

• Most frequent: akathisia (19%) and parkinsonism (17.5%); other common reactions include sedation, dizziness, insomnia, anxiety, weight gain, nausea, vomiting, constipation, blurred vision, hypertension and raised CPK/hepatic enzymes.International label, same product · electronic medicines compendium (eMC)

• Hypersensitivity to cariprazine or any excipient; concomitant strong CYP3A4 inhibitors; concomitant strong or moderate CYP3A4 inducers.International label, same product · electronic medicines compendium (eMC)

• Suicidal thoughts and behaviour: close supervision of high-risk patients.International label, same product · electronic medicines compendium (eMC)
• Akathisia and restlessness, typically early in treatment; tardive dyskinesia (consider discontinuation).International label, same product · electronic medicines compendium (eMC)
• Not recommended in elderly patients with dementia (increased mortality and cerebrovascular adverse events with antipsychotics).International label, same product · electronic medicines compendium (eMC)

• Strong CYP3A4 inhibitors (e.g. ketoconazole, itraconazole, clarithromycin, ritonavir)Ketoconazole about doubled total cariprazine exposure; contraindicated.electronic medicines compendium (eMC)
• Strong/moderate CYP3A4 inducers (e.g. rifampicin, carbamazepine, phenytoin, St John's wort)Markedly reduced exposure; contraindicated.electronic medicines compendium (eMC)
• Moderate CYP3A4 inhibitors (e.g. erythromycin)About 1.4-fold increase in exposure; not recommended.electronic medicines compendium (eMC)

• Not recommended during pregnancy or in women of childbearing potential not using effective contraception, which should continue for at least 10 weeks after the last dose. Neonates exposed in the third trimester are at risk of extrapyramidal and/or withdrawal symptoms.International label, same product · electronic medicines compendium (eMC)
• Breast-feeding should be discontinued during treatment.International label, same product · electronic medicines compendium (eMC)

• Cariprazine: Partial agonist at dopamine D3, D2 and serotonin 5-HT1A receptors and antagonist at 5-HT2B, 5-HT2A and histamine H1 receptors (UK SmPC).