سعر رينوبلاستين 20مجم 10 اقراص 2022

Rhinobilastin 20 mg tablets, pack of 10 (Hikma Pharma, under licence from Faes Farma, Egypt): bilastine, a second-generation non-sedating H1 antihistamine.

• Symptomatic treatment of allergic rhino-conjunctivitis (seasonal and perennial) and urticaria.Population: Adults and adolescents 12 years and overelectronic medicines compendium (emc)

• Adverse event incidence with 20 mg was comparable with placebo (12.7% vs 12.8%); most commonly reported: headache, somnolence, dizziness and fatigue.International label, same formulation · electronic medicines compendium (emc)

• Hypersensitivity to bilastine or any excipient.International label, same formulation · electronic medicines compendium (emc)

• In moderate or severe renal impairment, avoid coadministration with P-glycoprotein inhibitors (e.g. ketoconazole, erythromycin, cyclosporine, ritonavir, diltiazem).International label, same formulation · electronic medicines compendium (emc)

• Ketoconazole, erythromycin (P-gp inhibitors)Increased bilastine AUC about 2-fold and Cmax 2-3-fold; safety profile not apparently affected.electronic medicines compendium (emc)
• Grapefruit and other fruit juicesGrapefruit juice decreased bilastine bioavailability by 30% (OATP1A2 inhibition).electronic medicines compendium (emc)

• No or limited data in pregnant women; animal studies show no harmful effects; as a precaution, preferable to avoid use during pregnancy.International label, same formulation · electronic medicines compendium (emc)
• Excretion in human milk not studied (excreted in animal milk); decide whether to stop breast-feeding or bilastine considering benefits to child and mother.International label, same formulation · electronic medicines compendium (emc)