سعر استين 20 مجم 20 قرص 2025

Astin (ebastine 20 mg) film-coated tablets by Future Pharmaceutical Industries (FPI), a second-generation H1-antihistamine; pack of 20 tablets.

• Symptomatic treatment of allergic rhinitis (seasonal and perennial), with or without allergic conjunctivitisPopulation: Adults and children over 12 yearsCIMA (AEMPS)
• Chronic idiopathic urticariaPopulation: Adults and children over 12 yearsCIMA (AEMPS)
• Allergic dermatitisPopulation: Adults and children over 12 yearsCIMA (AEMPS)

• Most frequently reported: headache (very common), dry mouth and somnolence (common). Rare: hypersensitivity reactions (anaphylaxis, angioedema), nervousness, insomnia, dizziness, hypoaesthesia, dysgeusia, palpitations, tachycardia, abdominal pain, vomiting, nausea, dyspepsia, hepatitis/cholestasis and abnormal liver tests.International label, same formulation · CIMA (AEMPS)

• Hypersensitivity to ebastine or any excipient.International label, same formulation · CIMA (AEMPS)

• Use with caution in patients with known cardiac risk such as QT prolongation, hypokalaemia, or concomitant QT-prolonging drugs or CYP3A4 inhibitors (azole antifungals such as ketoconazole and itraconazole, macrolides such as erythromycin).International label, same formulation · CIMA (AEMPS)
• Because the therapeutic effect starts 1-3 hours after administration, it should not be used for acute emergency allergic conditions.International label, same formulation · CIMA (AEMPS)
• Use with caution in severe hepatic impairment; pharmacokinetic interaction possible with rifampicin.International label, same formulation · CIMA (AEMPS)

• Ketoconazole, itraconazole, erythromycin (CYP3A4 inhibitors)Increase ebastine plasma levels and may prolong the QT interval; use with caution.CIMA (AEMPS)
• RifampicinPharmacokinetic interaction; may reduce ebastine exposure and effect.CIMA (AEMPS)

• Limited human data; animal studies show no harmful effects; as a precaution it is preferable to avoid ebastine during pregnancy.International label, same formulation · CIMA (AEMPS)
• Unknown whether ebastine is excreted in breast milk; as a precaution it is preferable to avoid use during breastfeeding.International label, same formulation · CIMA (AEMPS)

• Ebastine: Potent, long-acting, highly selective H1-receptor antagonist; the active acid metabolite carebastine parallels the antihistamine effect; does not cross the blood-brain barrier appreciably (Spanish SmPC).