سعر ريفامبسون 150/300مجم 10 كبسول 2022

Fixed-dose oral capsule of isoniazid and rifampicin (listed as 150/300 mg), pack of 10, by Memphis.

• Treatment of all forms of tuberculosis, including fresh, advanced and chronic casesPopulation: Adultselectronic medicines compendium (eMC)

• Rifampicin: pyrexia, chills (very common); nausea, vomiting, headache, dizziness, thrombocytopenia, raised bilirubin/transaminases (common).International label, equivalent formulation · electronic medicines compendium (eMC)
• Isoniazid: polyneuritis, convulsions, optic neuritis, hepatitis, rash, haematological disorders.International label, equivalent formulation · electronic medicines compendium (eMC)

• Hypersensitivity to rifamycins, isoniazid or excipients; jaundice.International label, equivalent formulation · electronic medicines compendium (eMC)
• Concurrent saquinavir/ritonavir; lurasidone, sofosbuvir, daclatasvir, telaprevir, cabotegravir, fostemsavir, lenacapavir.International label, equivalent formulation · electronic medicines compendium (eMC)

• Both components are associated with liver dysfunction; pre-treatment liver function tests; monthly transaminases in patients over 35 years.International label, equivalent formulation · electronic medicines compendium (eMC)
• Thrombotic microangiopathy, DRESS and severe cutaneous reactions (SJS, TEN, AGEP): withdraw immediately.International label, equivalent formulation · electronic medicines compendium (eMC)
• Isoniazid: severe, sometimes fatal hepatitis; peripheral neuropathy risk (slow acetylators, malnutrition, diabetes, alcohol, HIV) - pyridoxine may be required.International label, equivalent formulation · electronic medicines compendium (eMC)

• Drugs metabolised by CYP450/UGT/P-gpRifampicin potently induces metabolising enzymes and transporters; dose adjustment or avoidance of many co-medications needed.electronic medicines compendium (eMC)
• Tyramine/histamine-rich foodsIsoniazid inhibits MAO and DAO; avoid cured meat, matured cheese, wine, beer and some fish.electronic medicines compendium (eMC)
• Hormonal contraceptivesReduced exposure; use non-hormonal contraception.electronic medicines compendium (eMC)

• Use in pregnancy only if potential benefit justifies potential risk to the fetus.International label, equivalent formulation · electronic medicines compendium (eMC)
• Both drugs pass into breast milk; breastfeed only if benefit outweighs risk; monitor infant and consider pyridoxine for mother and infant.International label, equivalent formulation · electronic medicines compendium (eMC)

• Isoniazid: Acts against actively growing tubercle bacilli.
• Rifampicin: Inhibits bacterial DNA-dependent RNA polymerase.