سعر ريوزيد 150/300مجم 8 كبسولات 2024

Fixed-dose combination of isoniazid 150 mg and rifampicin 300 mg oral capsules, pack of 8, marketed in Egypt by MUP.

• Treatment of all forms of tuberculosis, including fresh, advanced and chronic cases.Population: Adultselectronic medicines compendium (eMC)

• Rifampicin: very common pyrexia and chills; common thrombocytopenia, headache, dizziness, nausea, vomiting, raised bilirubin/AST/ALT, paradoxical reaction; also hepatitis, severe skin reactions and body-fluid discolouration.International label, equivalent formulation · electronic medicines compendium (eMC)
• Isoniazid: uncommon severe hepatitis and neurotoxic effects (convulsions, optic neuritis, toxic psychosis); polyneuritis more frequent in slow acetylators; also rash, blood disorders, pellagra, hyperglycaemia, gynaecomastia.International label, equivalent formulation · electronic medicines compendium (eMC)

• Hypersensitivity to rifamycins, isoniazid or any excipient.International label, equivalent formulation · electronic medicines compendium (eMC)
• Jaundice.International label, equivalent formulation · electronic medicines compendium (eMC)
• Concurrent saquinavir/ritonavir.International label, equivalent formulation · electronic medicines compendium (eMC)

• Both components are associated with liver dysfunction; severe and sometimes fatal hepatitis (isoniazid, age-related) and drug-induced liver injury (rifampicin) reported.International label, equivalent formulation · electronic medicines compendium (eMC)
• Severe hypersensitivity including DRESS and severe cutaneous reactions (SJS, TEN, AGEP); withdraw immediately and do not restart.International label, equivalent formulation · electronic medicines compendium (eMC)
• Thrombotic microangiopathy (TTP/HUS), including fatal cases: discontinue and evaluate.International label, equivalent formulation · electronic medicines compendium (eMC)

• CYP450/UGT/P-gp substrates (e.g. coumarins, hormonal contraceptives, corticosteroids, ciclosporin, tacrolimus, azole antifungals, many antiretrovirals)Rifampicin is a potent inducer of CYP1A2, 2B6, 2C8, 2C9, 2C19, 3A4, UGT and P-gp and may reduce exposure of many co-administered drugs; dose adjustment may be needed when starting or stopping.electronic medicines compendium (eMC)
• Hormonal contraceptivesReduced systemic exposure; patients should change to non-hormonal contraception.electronic medicines compendium (eMC)
• AntacidsReduce absorption of rifampicin and isoniazid; give rifampicin at least 1 hour before antacids.electronic medicines compendium (eMC)

• No well controlled studies in pregnant women; rifampicin is teratogenic in rodents at large doses. Use in pregnancy or women of child-bearing potential only if benefit justifies risk.International label, equivalent formulation · electronic medicines compendium (eMC)
• Both drugs pass into breast milk; breastfeeding only if benefit outweighs risk; monitor infant and consider pyridoxine for mother and infant.International label, equivalent formulation · electronic medicines compendium (eMC)

• Isoniazid: Bactericidal against actively growing tubercle bacilli.
• Rifampicin: Inhibits bacterial DNA-dependent RNA polymerase; does not inhibit the mammalian enzyme.