سعر رايت-إيس كومب 5/25 مجم أقراص 2022

Fixed-dose combination tablet of ramipril 5 mg (ACE inhibitor) and hydrochlorothiazide 25 mg (thiazide diuretic), pack of 30, marketed in Egypt by Adwia.

• Treatment of hypertension in patients whose blood pressure is not adequately controlled with ramipril alone or hydrochlorothiazide alonePopulation: AdultsSwedish Medical Products Agency (Läkemedelsverket)

• Safety profile reflects hypotension/fluid depletion; ramipril may cause persistent dry cough, hydrochlorothiazide may worsen glucose, lipid and uric acid metabolism. Common: headache, dizziness, non-productive tickling cough, bronchitis. Serious: angioedema/anaphylaxis, renal or hepatic impairment, pancreatitis, severe skin reactions, neutropenia/agranulocytosis. Non-melanoma skin cancer reported (frequency not known).International label, same formulation · Swedish Medical Products Agency (Läkemedelsverket)

• Hypersensitivity to ramipril or other ACE inhibitors, hydrochlorothiazide, other thiazides, sulphonamides or excipients.International label, same formulation · Swedish Medical Products Agency (Läkemedelsverket)
• History of angioedema (hereditary, idiopathic or with previous ACE inhibitor/AIIRA).International label, same formulation · Swedish Medical Products Agency (Läkemedelsverket)
• Severe renal impairment (CrCl <30 ml/min, undialysed), severe hepatic impairment, hepatic encephalopathy, clinically relevant electrolyte disturbances.International label, same formulation · Swedish Medical Products Agency (Läkemedelsverket)

• ACE inhibitors should not be initiated during pregnancy; stop immediately when pregnancy is diagnosed.International label, same formulation · Swedish Medical Products Agency (Läkemedelsverket)
• Risk of hypotension in patients with strongly activated renin-angiotensin-aldosterone system or on diuretics; consider reducing or stopping the diuretic before starting.International label, same formulation · Swedish Medical Products Agency (Läkemedelsverket)
• Concomitant neprilysin inhibitors (e.g. racecadotril), mTOR inhibitors and vildagliptin may increase angioedema risk.International label, same formulation · Swedish Medical Products Agency (Läkemedelsverket)

• Contraindicated during lactation.International label, same formulation · Swedish Medical Products Agency (Läkemedelsverket)

• Ramipril: Prodrug hydrolysed to ramiprilat, which inhibits angiotensin-converting enzyme, reducing angiotensin II formation and aldosterone secretion.
• Hydrochlorothiazide: Promotes renal excretion of sodium and chloride, reducing intravascular volume.