سعر سافابران 7.5مجم 20 اقراص 2022

Savapran 7.5 mg film-coated tablets (Horus for Pharmaceutical Products / Eva Pharma, Egypt), ivabradine 7.5 mg, pack of 20 tablets (2 strips); listed in Egypt as an anti-ischaemic agent.

• Symptomatic treatment of chronic stable angina pectoris in coronary artery disease adults with normal sinus rhythm and heart rate >= 70 bpm, if beta-blockers are not tolerated/contraindicated or in combination with beta-blockers when inadequately controlledPopulation: Adultselectronic medicines compendium (emc), UK
• Chronic heart failure NYHA II-IV with systolic dysfunction, in sinus rhythm with heart rate >= 75 bpm, with standard therapy including beta-blocker or when beta-blockers are contraindicated/not toleratedPopulation: Adultselectronic medicines compendium (emc), UK
• US: to reduce the risk of hospitalisation for worsening heart failure in adults with stable, symptomatic chronic heart failure with reduced LVEF; stable symptomatic heart failure due to dilated cardiomyopathy in paediatric patients aged 6 months and olderDailyMed (U.S. National Library of Medicine)

• Very common: luminous phenomena (phosphenes, 14.5%). Common: bradycardia, first-degree AV block, ventricular extrasystoles, atrial fibrillation, headache, dizziness, blurred vision, uncontrolled blood pressure. Uncommon: eosinophilia, hyperuricaemia, syncope, diplopia, vertigo, palpitations, QT prolongation, hypotension, dyspnoea, GI upset, angioedema, rash, muscle spasms, raised creatinine. Very rare: second/third-degree AV block, sick sinus syndrome.International label, same formulation · electronic medicines compendium (emc), UK

• Resting heart rate below 70 bpm before treatment; cardiogenic shock; acute myocardial infarction; severe hypotension (< 90/50 mmHg); severe hepatic insufficiency; sick sinus syndrome; sino-atrial block; unstable or acute heart failure; pacemaker dependence; unstable angina; third-degree AV block; combination with strong CYP3A4 inhibitors or with verapamil/diltiazem; pregnancy, lactation and women of child-bearing potential not using appropriate contraception; hypersensitivity.International label, same formulation · electronic medicines compendium (emc), UK

• No benefit on cardiovascular outcomes in stable angina (symptomatic use only). Not effective for arrhythmias; increased risk of atrial fibrillation; not recommended with second-degree AV block or immediately after stroke.International label, same formulation · electronic medicines compendium (emc), UK
• Down-titrate or stop if resting HR persistently < 50 bpm or bradycardia symptoms; avoid with QT-prolonging drugs or congenital long QT; caution in retinitis pigmentosa, mild-moderate hypotension and NYHA IV heart failure; contains lactose.International label, same formulation · electronic medicines compendium (emc), UK
• Transient luminous phenomena (phosphenes) may affect driving, especially at night.International label, same formulation · electronic medicines compendium (emc), UK

• Strong CYP3A4 inhibitors (azole antifungals, macrolides such as clarithromycin, HIV protease inhibitors, nefazodone)Increase ivabradine exposure 7- to 8-fold; contraindicated.electronic medicines compendium (emc), UK
• Verapamil, diltiazem2- to 3-fold increase in exposure and additional heart-rate reduction; contraindicated.electronic medicines compendium (emc), UK
• QT-prolonging medicines (e.g. quinidine, sotalol, amiodarone, pimozide, IV erythromycin)QT prolongation may be exacerbated by heart-rate reduction; avoid or monitor closely.electronic medicines compendium (emc), UK

• Limited human data; animal studies showed embryotoxic and teratogenic effects; contraindicated in pregnancy; women of child-bearing potential should use appropriate contraception.International label, same formulation · electronic medicines compendium (emc), UK
• Excreted in animal milk; contraindicated during breast-feeding; women needing treatment should stop breast-feeding.International label, same formulation · electronic medicines compendium (emc), UK

• Ivabradine: Selectively inhibits the cardiac pacemaker If current in the sinoatrial node, slowing diastolic depolarisation and lowering heart rate without affecting contractility.