سعر سبانيلا ام ار 35مجم 30 قرص 2025

Trimetazidine 35 mg modified-release film-coated tablets, pack of 30 (Marcyrl, Egypt); metabolic anti-ischaemic agent.

• Add-on therapy for symptomatic treatment of stable angina pectoris in adults inadequately controlled by or intolerant to first-line antianginal therapies.Population: AdultsServier (myservier-me.com)

• Common: dizziness, headache, abdominal pain, diarrhoea, dyspepsia, nausea, vomiting, rash, pruritus, urticaria, asthenia. Not known: parkinsonian symptoms, restless legs, sleep disorders, thrombocytopenia, agranulocytosis, hepatitis, AGEP.International label, same formulation · Servier (myservier-me.com)

• Hypersensitivity; Parkinson disease, parkinsonian symptoms, tremors, restless legs syndrome and related movement disorders; severe renal impairment (CrCl <30 mL/min).International label, same formulation · Servier (myservier-me.com)

• Not for treatment of angina attacks, unstable angina or myocardial infarction; can cause or worsen parkinsonian symptoms (stop permanently if movement disorders occur); falls from postural instability or hypotension; caution in moderate renal impairment and over 75 years; may give positive anti-doping tests.International label, same formulation · Servier (myservier-me.com)

• Antihypertensive treatmentFalls related to hypotension may occur, particularly in patients taking antihypertensives (the SmPC states no drug interaction has been identified).Servier (myservier-me.com)

• No data in pregnant women; animal studies showed no harm; as a precaution avoid during pregnancy.International label, same formulation · Servier (myservier-me.com)
• Unknown whether excreted in breast milk; should not be used during breastfeeding.International label, same formulation · Servier (myservier-me.com)

• Trimetazidine: Inhibits fatty acid beta-oxidation by blocking 3-ketoacyl-CoA thiolase, shifting myocardial metabolism to glucose oxidation and preserving ATP in ischaemic cells.