سعر نابيبرادين 5 مجم 30 قرص 2024

Napibradine ivabradine 5 mg film-coated tablets, 30 tablets (Global Napi); HCN/If-channel blocker that lowers sinus heart rate.

• To reduce the risk of hospitalization for worsening heart failure in adults with stable, symptomatic chronic heart failure with LVEF ≤35%, in sinus rhythm with resting heart rate ≥70 bpm, on maximally tolerated beta-blocker doses or with a contraindication to beta-blockers.Population: AdultsDailyMed (U.S. National Library of Medicine)
• Treatment of stable symptomatic heart failure due to dilated cardiomyopathy in pediatric patients aged 6 months and older in sinus rhythm with an elevated heart rate.Population: Pediatric patients 6 months and olderDailyMed (U.S. National Library of Medicine)

• Most common adverse reactions (≥1%): bradycardia, hypertension, atrial fibrillation and luminous phenomena (phosphenes).International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Acute decompensated heart failure; clinically significant hypotension; sick sinus syndrome, sinoatrial block or third-degree AV block unless a functioning demand pacemaker is present; clinically significant bradycardia.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Severe hepatic impairment; pacemaker dependence; concomitant use of strong CYP3A4 inhibitors.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Fetal toxicity: may cause fetal harm based on animal studies; females of reproductive potential should use effective contraception.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Increases the risk of atrial fibrillation; monitor cardiac rhythm regularly and discontinue if atrial fibrillation develops.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Bradycardia, sinus arrest and heart block have occurred; bradycardia may increase the risk of QT prolongation and serious ventricular arrhythmias; avoid concurrent verapamil or diltiazem and avoid use in second-degree AV block unless a demand pacemaker is present.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Strong CYP3A4 inhibitors (e.g. itraconazole, clarithromycin, nelfinavir, nefazodone)Contraindicated: increase ivabradine concentrations and may worsen bradycardia and conduction disturbances.DailyMed (U.S. National Library of Medicine)
• Moderate CYP3A4 inhibitors (diltiazem, verapamil, grapefruit juice)Avoid concomitant use.DailyMed (U.S. National Library of Medicine)
• CYP3A4 inducers (St John's wort, rifampicin, barbiturates, phenytoin)Avoid concomitant use (decrease ivabradine concentrations).DailyMed (U.S. National Library of Medicine)

• Based on animal findings ivabradine may cause fetal harm; there are no adequate studies in pregnant women; advise pregnant women of the potential risk to the fetus.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• No human data; ivabradine is present in rat milk; because of the potential risk to breastfed infants, breastfeeding is not recommended.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Ivabradine: Selectively inhibits the If ("funny") current in the sinoatrial node, slowing diastolic depolarisation and lowering heart rate without affecting contractility.