سعر سيبتانيست ان 4% كارب 1.8 مل ابينفرين 1:200000 2022

Septanest is a dental local anaesthetic injection containing articaine hydrochloride 4% with epinephrine 1:200,000 in cartridges, listed in Egypt under The Multinational Co. For Drugs-Egypt.

• Local and loco-regional anaesthesia in dental procedures (adults, adolescents and children from 4 years / 20 kg).Population: Adults, adolescents and children >= 4 yearsSeptodont Ltd (UK) / MHRA

• Common: headache, oral/perioral hypoaesthesia or dysaesthesia, neuropathic pain, gingivitis, bradycardia or tachycardia, hypotension, swelling of tongue, lip or gums. Rare: allergic/anaphylactic reactions, facial nerve palsy, Horner syndrome, diplopia, injection-site necrosis. Very rare: persistent paraesthesia after mandibular/inferior alveolar nerve block.International label, same formulation · Septodont Ltd (UK) / MHRA

• Hypersensitivity to articaine or any amide-type local anaesthetic, to adrenaline or to any excipient (including sodium metabisulfite); epilepsy not controlled by treatment.International label, same formulation · Septodont Ltd (UK) / MHRA

• Use the lowest effective dose and consider postponing treatment in significant cardiovascular disease: conduction disturbances, acute heart failure, hypotension, tachyarrhythmias, unstable angina or myocardial infarction within 6 months, coronary bypass within 3 months, uncontrolled hypertension, non-cardioselective beta-blockers or tricyclic antidepressants.International label, same formulation · Septodont Ltd (UK) / MHRA
• Caution in epilepsy, plasma cholinesterase deficiency, myasthenia gravis on acetylcholinesterase inhibitors, porphyria (use in acute porphyria only if no safer alternative), severe hepatic or renal disease, and patients on antiplatelets/anticoagulants (bleeding risk).International label, same formulation · Septodont Ltd (UK) / MHRA
• Contains sodium metabisulfite, which may rarely cause allergic-type reactions and bronchospasm.International label, same formulation · Septodont Ltd (UK) / MHRA

• Non-cardioselective beta-blockers (e.g. propranolol)Risk of hypertensive crisis or severe bradycardia with the adrenaline component; use the lowest effective dose.Septodont Ltd (UK) / MHRA
• Tricyclic antidepressantsMay intensify the cardiovascular effects of adrenaline.Septodont Ltd (UK) / MHRA
• Sympathomimetic vasopressors (e.g. cocaine, amphetamines, phenylephrine, pseudoephedrine, oxymetazoline)Risk of adrenergic toxicity; postpone dental treatment if used within 24 hours.Septodont Ltd (UK) / MHRA

• Animal studies showed no adverse effects of articaine/adrenaline on pregnancy or fetal development; no experience in pregnant women except at childbirth. Use only after careful benefit-risk analysis; the 1:200,000 strength is preferred over 1:100,000 because of its lower adrenaline content.International label, same formulation · Septodont Ltd (UK) / MHRA
• Clinically relevant amounts of articaine are not found in breast milk; breastfeeding usually need not be suspended for short-term use, resuming from 5 hours after anaesthesia.International label, same formulation · Septodont Ltd (UK) / MHRA

• Articaine hydrochloride: Blocks generation and conduction of nerve impulses by reducing sodium permeability of the nerve membrane.
• Epinephrine (adrenaline): Local vasoconstriction slows absorption of the anaesthetic and prolongs anaesthesia.