سعر سوليان 400مجم 30 اقراص 2022

Amisulpride 400 mg scored tablets (30 tablets), a substituted benzamide antipsychotic, marketed in Egypt by Sanofi.

• Acute and chronic schizophrenic disorders with prominent positive and/or negative symptoms, including predominant negative symptomsPopulation: Adultselectronic medicines compendium (eMC)

• Very common: extrapyramidal symptoms (tremor, rigidity, hypokinesia, hypersalivation, akathisia, dyskinesia). Common: somnolence, acute dystonia, blurred vision, hypotension, raised prolactin (galactorrhoea, amenorrhoea, gynaecomastia, breast pain, erectile dysfunction).International label, same formulation · electronic medicines compendium (eMC)
• Uncommon/rare: seizures, tardive dyskinesia, hyperglycaemia, leukopenia/neutropenia, bradycardia; rare: neuroleptic malignant syndrome, agranulocytosis, QT prolongation and ventricular arrhythmias (torsade de pointes), venous thromboembolism, hyponatraemia/SIADH, prolactinoma.International label, same formulation · electronic medicines compendium (eMC)

• Hypersensitivity; concomitant prolactin-dependent tumours (e.g. pituitary prolactinoma, breast cancer); phaeochromocytoma; children before puberty; combination with levodopa.International label, same formulation · electronic medicines compendium (eMC)

• Neuroleptic malignant syndrome (potentially fatal) may occur: stop all antipsychotics if suspected. Rhabdomyolysis has also been reported.International label, same formulation · electronic medicines compendium (eMC)
• QT prolongation: caution in known cardiovascular disease or family history of QT prolongation; avoid with other neuroleptics.International label, same formulation · electronic medicines compendium (eMC)
• Hyperglycaemia reported: glycaemic monitoring in diabetes or diabetes risk factors. May lower the seizure threshold (monitor epilepsy). Caution in Parkinson's disease and in patients with stroke risk factors (increased cerebrovascular events in elderly dementia patients on atypical antipsychotics).International label, same formulation · electronic medicines compendium (eMC)

• LevodopaContraindicated: reciprocal antagonism of effects between levodopa and neuroleptics.electronic medicines compendium (eMC)
• AlcoholNot recommended: amisulpride may enhance the central effects of alcohol.electronic medicines compendium (eMC)
• QT-prolonging medicines (class IA/III antiarrhythmics, some antihistamines, other antipsychotics, mefloquine)Caution: additive risk of QT prolongation.electronic medicines compendium (eMC)

• Limited human data; amisulpride crosses the placenta and animal studies showed reproductive toxicity. Not recommended in pregnancy or in women of childbearing potential without effective contraception unless benefits justify the risks.International label, same formulation · electronic medicines compendium (eMC)
• Excreted into breast milk in relatively large amounts; decide whether to stop breastfeeding or abstain from therapy.International label, same formulation · electronic medicines compendium (eMC)

• Amisulpride: Binds selectively with high affinity to dopamine D2/D3 receptors, with no affinity for D1, D4, D5, serotonin, alpha-adrenergic, H1 or cholinergic receptors (UK SmPC 5.1).