سعر سبيركس 3 مليون وحدة دولية 10 اقراص 2025

Spirex 3 M.I.U. film-coated tablets (Medical Union Pharmaceuticals, Egypt), pack of 10: spiramycin 3 million IU (704 mg) per tablet, a macrolide antibiotic.

• Documented group A beta-haemolytic streptococcal tonsillitis/pharyngitis, as an alternative to beta-lactams, particularly when these cannot be used.Population: AdultsAsafar (Moroccan medicines database based on AMMPS/ANAM data)
• Acute sinusitis, when beta-lactam treatment is impossible.Population: AdultsAsafar (Moroccan medicines database based on AMMPS/ANAM data)
• Superinfection of acute bronchitis; exacerbations of chronic bronchitis.Population: AdultsAsafar (Moroccan medicines database based on AMMPS/ANAM data)

• Spiramycin: hypersensitivity to spiramycin or to any excipient.International label, same formulation · Base de données publique des médicaments (ANSM, France)

• Spiramycin: severe cutaneous reactions (Stevens-Johnson syndrome, toxic epidermal necrolysis, acute generalised exanthematous pustulosis) have been reported; stop treatment and do not re-use spiramycin alone or combined.International label, same formulation · Base de données publique des médicaments (ANSM, France)
• Spiramycin: very rare haemolytic anaemia in glucose-6-phosphate dehydrogenase (G6PD) deficiency; use not recommended in these patients.International label, same formulation · Base de données publique des médicaments (ANSM, France)
• Spiramycin: QT prolongation reported with macrolides; use with caution in patients with risk factors (uncorrected hypokalaemia or hypomagnesaemia, congenital long QT, heart disease, QT-prolonging drugs).International label, same formulation · Base de données publique des médicaments (ANSM, France)

• Torsadogenic (QT-prolonging) drugsSpiramycin: increased risk of ventricular arrhythmias, notably torsades de pointes.Base de données publique des médicaments (ANSM, France)
• Levodopa/carbidopaSpiramycin inhibits carbidopa absorption, lowering levodopa plasma levels; monitor and adjust levodopa dose.Base de données publique des médicaments (ANSM, France)
• Oral anticoagulants (vitamin K antagonists)INR imbalance reported with antibiotics (macrolides among the classes most involved); monitor INR.Base de données publique des médicaments (ANSM, France)

• Spiramycin may be considered during pregnancy if needed; wide use in pregnancy has not shown malformative or foetotoxic effects to date.International label, same formulation · Asafar (Moroccan medicines database based on AMMPS/ANAM data)
• Passage into breast milk is significant and digestive disorders have been described in newborns; breastfeeding is not advised during treatment.International label, same formulation · Asafar (Moroccan medicines database based on AMMPS/ANAM data)

• Spiramycin: Macrolide: binds the 50S subunit of bacterial ribosomes, blocking transpeptidation and inhibiting protein synthesis; primarily bacteriostatic, possibly bactericidal against more sensitive strains at high concentrations.