سعر تي بي زايد 50 مجم 100 قرص 2022

Isoniazid 50 mg oral tablets, pack of 100 tablets, antitubercular agent marketed in Egypt by El Nasr.

• All forms of tuberculosis caused by susceptible organisms (active TB only in combination with other antituberculosis drugs); preventive therapy in specified risk groupsDailyMed (U.S. National Library of Medicine)

• Most frequent reactions affect the nervous system and liver; peripheral neuropathy is the most common toxic effect, dose-related and more frequent in malnourished, alcoholic and diabetic patients.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Severe hypersensitivity reactions including drug-induced hepatitis; previous isoniazid-associated hepatic injury; severe adverse reactions such as drug fever, chills, arthritis; acute liver disease of any cause.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Boxed warning: severe and sometimes fatal hepatitis, which may develop even after many months; risk rises with age and with daily alcohol use.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• PhenytoinIsoniazid may increase phenytoin serum levels; adjust the anticonvulsant dose.DailyMed (U.S. National Library of Medicine)
• Acetaminophen (paracetamol)Severe acetaminophen toxicity reported; isoniazid may increase formation of toxic metabolites.DailyMed (U.S. National Library of Medicine)
• AlcoholDaily alcohol ingestion is associated with a higher incidence of isoniazid hepatitis.DailyMed (U.S. National Library of Medicine)

• Embryocidal in rats and rabbits but not teratogenic in animal studies; no adequate studies in pregnant women; crosses the placenta, so observe neonates of treated mothers.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Small concentrations in breast milk do not produce toxicity in the nursing newborn; breastfeeding should not be discouraged, but milk levels cannot be relied on for infant prophylaxis or therapy.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Isoniazid: Bactericidal; inhibits mycolic acid synthesis needed for the mycobacterial cell wall.