سعر ايزوسيد 100 مجم 20 قرص 2022

Isocid 100 mg (CID): isoniazid 100 mg oral tablets, pack of 20 (2 strips); an antituberculosis drug used in combination regimens and for chemoprophylaxis.

• Treatment of tuberculosis in combination with rifampicin, pyrazinamide and ethambutol (initial and continuation phases), and tuberculosis chemoprophylaxis for 6 months in high-risk patients.Population: Adults and childrenCID Export (CID pharmaceutical company product gallery)
• Treatment of all forms of pulmonary and extra-pulmonary tuberculosis.Population: Adults and children aged 3 months and aboveelectronic medicines compendium (emc), UK
• US label: all forms of tuberculosis caused by susceptible organisms (always with other antituberculosis drugs for active disease), and preventive therapy in defined high-risk groups.Population: All agesDailyMed (U.S. National Library of Medicine)

• Uncommon: hepatitis. Rare: optic atrophy, toxic epidermal necrolysis, DRESS. Frequency not known: peripheral neuropathy, seizures, optic neuritis, psychotic disorder, haemolytic and aplastic anaemia, agranulocytosis, hypersensitivity (rash, fever, lymphadenopathy), hyper/hypoglycaemia, pellagra, lupus-like syndrome, nausea, vomiting, constipation, dry mouth, pancreatitis, acute hepatic failure, jaundice (risk rises with age, especially over 35), erythema multiforme, Stevens-Johnson syndrome, interstitial lung disease, gynaecomastia, vasculitis.International label, same formulation · electronic medicines compendium (emc), UK

• Hypersensitivity to isoniazid or excipients; previous severe adverse reaction to isoniazid, including drug-induced liver disease.International label, same formulation · electronic medicines compendium (emc), UK
• US label: severe hypersensitivity reactions including drug-induced hepatitis; previous isoniazid-associated hepatic injury; severe adverse reactions such as drug fever, chills, arthritis; acute liver disease of any etiology.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Baseline and regular liver function tests; withdraw if AST rises above three times normal or bilirubin rises, or if hepatitis symptoms (malaise, fatigue, anorexia, nausea) develop. Caution in convulsive disorders, diabetes, chronic alcoholism, hepatic or renal impairment, history of psychosis, and with other hepatotoxic drugs. Risk factors for hepatotoxicity: advanced age, female sex, slow acetylators, malnutrition, HIV, pre-existing liver disease. Give pyridoxine to patients at risk of neuropathy (diabetes, alcoholism, malnutrition, uraemia, pregnancy, HIV).International label, same formulation · electronic medicines compendium (emc), UK
• US boxed warning: severe and sometimes fatal hepatitis may occur even after many months of treatment; risk is age related and increased with daily alcohol use, chronic liver disease and injection drug use; monitor patients and measure transaminases in higher-risk groups.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Rifampicin and other hepatotoxic drugsIncreased risk of liver damage.electronic medicines compendium (emc), UK
• Carbamazepine, phenytoin, primidoneIsoniazid inhibits their hepatic metabolism; marked rises in carbamazepine levels and toxicity at isoniazid doses of 200 mg daily or more; phenytoin dose adjustment may be needed.electronic medicines compendium (emc), UK
• Diazepam, triazolam (benzodiazepines)Increased risk of benzodiazepine toxicity (sedation, respiratory depression).electronic medicines compendium (emc), UK

• Isoniazid crosses the placenta; use in pregnancy only if benefit justifies risk; untreated tuberculosis is a far greater hazard to mother and fetus than treatment. Pyridoxine supplementation is recommended.International label, same formulation · electronic medicines compendium (emc), UK
• Passes into breast milk; monitor breast-fed infants for signs of isoniazid toxicity; pyridoxine for mother and infant may be considered.International label, same formulation · electronic medicines compendium (emc), UK

• Isoniazid: Inhibits mycolic acid synthesis and disrupts the mycobacterial cell wall; active mainly against actively dividing mycobacteria.