سعر Thiozin 50 مجم 2026

دواعي استعمال Thiozin

Management of schizophrenic patients who fail to respond adequately to treatment with other antipsychotic drugs (reserved because of QTc-prolongation risk).الفئة: Adults and pediatric patients with schizophreniaDailyMed (U.S. National Library of Medicine)

Management of schizophrenic patients who fail to respond adequately to treatment with other antipsychotic drugs (reserved because of QTc-prolongation risk).Population: Adults and pediatric patients with schizophreniaDailyMed (U.S. National Library of Medicine)

عن الدواءAbout the medicine

Thiozin 50 mg: thioridazine (phenothiazine antipsychotic) oral film-coated tablets by Delta Pharma, Egypt; pack of 20.

الآثار الجانبيةSide effects

In recommended dose ranges most side effects are mild and transient; reported effects include endocrine disturbances (menstrual irregularities, gynecomastia, lactation, weight gain), urinary retention/incontinence and paradoxical behavioural reactions.نشرة دولية لتركيبة مكافئة · DailyMed (U.S. National Library of Medicine)

In recommended dose ranges most side effects are mild and transient; reported effects include endocrine disturbances (menstrual irregularities, gynecomastia, lactation, weight gain), urinary retention/incontinence and paradoxical behavioural reactions.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

موانع الاستعمالContraindications

Combination with other drugs known to prolong the QTc interval, and patients with congenital long QT syndrome or a history of cardiac arrhythmias.نشرة دولية لتركيبة مكافئة · DailyMed (U.S. National Library of Medicine)
Coadministration with CYP2D6 inhibitors (e.g. fluoxetine, paroxetine) or with fluvoxamine, propranolol or pindolol; patients known to have reduced CYP2D6 activity (about 7% of the population).نشرة دولية لتركيبة مكافئة · DailyMed (U.S. National Library of Medicine)
Patients with a QTc interval greater than 450 msec should not receive thioridazine.نشرة دولية لتركيبة مكافئة · DailyMed (U.S. National Library of Medicine)

Combination with other drugs known to prolong the QTc interval, and patients with congenital long QT syndrome or a history of cardiac arrhythmias.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
Coadministration with CYP2D6 inhibitors (e.g. fluoxetine, paroxetine) or with fluvoxamine, propranolol or pindolol; patients known to have reduced CYP2D6 activity (about 7% of the population).International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
Patients with a QTc interval greater than 450 msec should not receive thioridazine.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

تحذيرات واحتياطاتWarnings & precautions

Dose-related QTc prolongation with risk of torsades de pointes and sudden death; reserve for patients who failed at least two other antipsychotics.نشرة دولية لتركيبة مكافئة · DailyMed (U.S. National Library of Medicine)
Increased mortality in elderly patients with dementia-related psychosis treated with antipsychotic drugs.نشرة دولية لتركيبة مكافئة · DailyMed (U.S. National Library of Medicine)
Tardive dyskinesia and neuroleptic malignant syndrome may occur with antipsychotics.نشرة دولية لتركيبة مكافئة · DailyMed (U.S. National Library of Medicine)

Dose-related QTc prolongation with risk of torsades de pointes and sudden death; reserve for patients who failed at least two other antipsychotics.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
Increased mortality in elderly patients with dementia-related psychosis treated with antipsychotic drugs.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
Tardive dyskinesia and neuroleptic malignant syndrome may occur with antipsychotics.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

التداخلات الدوائيةDrug interactions

Fluoxetine, paroxetine and other CYP2D6 inhibitorsInhibit thioridazine metabolism, raising levels and QTc-related arrhythmia risk; contraindicated.DailyMed (U.S. National Library of Medicine)
FluvoxamineInhibits thioridazine metabolism; contraindicated.DailyMed (U.S. National Library of Medicine)
PropranololIncreases plasma thioridazine (about 50-400%) and metabolites; should not be coadministered.DailyMed (U.S. National Library of Medicine)

Fluoxetine, paroxetine and other CYP2D6 inhibitorsInhibit thioridazine metabolism, raising levels and QTc-related arrhythmia risk; contraindicated.DailyMed (U.S. National Library of Medicine)
FluvoxamineInhibits thioridazine metabolism; contraindicated.DailyMed (U.S. National Library of Medicine)
PropranololIncreases plasma thioridazine (about 50-400%) and metabolites; should not be coadministered.DailyMed (U.S. National Library of Medicine)

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