سعر ثيروكاربين Thyrocarbin‏ 5مجم 100 قرص 2026

Thyrocarbin carbimazole 5 mg film-coated tablets, pack of 100 (Royal Link Pharma, Egypt); antithyroid agent.

• Most frequent (usually in the first 8 weeks): nausea, headache, arthralgia, mild gastric distress, skin rash and pruritus. Rare: purpura, anaemia, pancytopenia/aplastic anaemia, neutropenia, leucopenia, thrombocytopenia; not known: agranulocytosis, angioedema, insulin autoimmune syndrome, neuritis.International label, equivalent formulation · Health Products Regulatory Authority (medicines.ie)

• Hypersensitivity to carbimazole or excipients; serious pre-existing haematological conditions; severe hepatic insufficiency; history of acute pancreatitis after carbimazole or thiamazole.International label, equivalent formulation · Health Products Regulatory Authority (medicines.ie)

• Bone marrow depression including agranulocytosis (sometimes fatal) has been reported: patients must stop the drug and seek advice immediately if sore throat, bruising or bleeding, mouth ulcers, fever or malaise develop; perform a white cell count.International label, equivalent formulation · Health Products Regulatory Authority (medicines.ie)
• Stop the drug and test liver function if signs of hepatic disorder (upper abdominal pain, anorexia, generalised pruritus) occur.International label, equivalent formulation · Health Products Regulatory Authority (medicines.ie)
• Acute pancreatitis has been reported; discontinue immediately and do not re-expose.International label, equivalent formulation · Health Products Regulatory Authority (medicines.ie)

• AnticoagulantsCarbimazole acts as a vitamin K antagonist; anticoagulant effect may be intensified - monitor PT/INR.Health Products Regulatory Authority (medicines.ie)
• TheophyllineSerum theophylline may rise as patients become euthyroid unless the dose is reduced.Health Products Regulatory Authority (medicines.ie)
• PrednisoloneIncreased prednisolone clearance.Health Products Regulatory Authority (medicines.ie)

• Use in pregnancy only after strict individual benefit/risk assessment at the lowest effective dose without added thyroid hormone; congenital malformations (e.g. aplasia cutis, choanal atresia, exomphalos, oesophageal atresia) are suspected, particularly with first-trimester and high-dose exposure; should be used in pregnancy only when propylthiouracil is not suitable. Blocking-replacement regimen should not be used in pregnancy.International label, equivalent formulation · Health Products Regulatory Authority (medicines.ie)
• Secreted in breast milk; if treatment continues during lactation the patient should not breast-feed.International label, equivalent formulation · Health Products Regulatory Authority (medicines.ie)

• Carbimazole: Prodrug rapidly metabolised to thiamazole (methimazole), which inhibits thyroid hormone synthesis.