سعر ترانكسين Tranexene‏ 5مجم 30 كبسولة 2026

Tranexene (dipotassium clorazepate) 5 mg capsules, pack of 30 (El Nile, under Sanofi Aventis).

• Very common: reduced alertness or somnolence (especially elderly); common: dependence with withdrawal or rebound on stopping, light-headedness, asthenia; uncommon: agitation, confusion, muscle hypotonia, rash, hypersensitivity; frequency not known: amnesia, behavioural disorders, falls, diplopia.International label, same formulation · Base de données publique des médicaments (ANSM)

• Hypersensitivity to the active substance or excipients.International label, same formulation · Base de données publique des médicaments (ANSM)
• Severe respiratory insufficiency.International label, same formulation · Base de données publique des médicaments (ANSM)
• Sleep apnoea syndrome.International label, same formulation · Base de données publique des médicaments (ANSM)

• Tolerance, physical and psychological dependence and withdrawal (insomnia, headache, anxiety, myalgia, rarely confusion, hallucinations, convulsions); abuse reported; risk rises with duration and dose.International label, same formulation · Base de données publique des médicaments (ANSM)
• Concomitant use with opioids can cause sedation, respiratory depression, coma and death; reserve for patients without adequate alternatives, at the lowest dose and shortest duration.International label, same formulation · Base de données publique des médicaments (ANSM)
• Anterograde amnesia, psychomotor impairment and paradoxical/behavioural reactions (agitation, aggressiveness, hallucinations) may occur; stop treatment if they do.International label, same formulation · Base de données publique des médicaments (ANSM)

• AlcoholNot advised: alcohol increases the sedative effect; avoid alcoholic drinks and alcohol-containing medicines.Base de données publique des médicaments (ANSM)
• Sodium oxybateNot advised: increased central depression.Base de données publique des médicaments (ANSM)
• Opioids (including tramadol) and buprenorphineIncreased risk of sedation, respiratory depression, coma and death; with substitution buprenorphine, potentially fatal respiratory depression.Base de données publique des médicaments (ANSM)

• Cohort data show no malformative effect with first-trimester benzodiazepine exposure, but some case-control studies found more cleft lip/palate (<2/1000 vs 1/1000 baseline). As a precaution, clorazepate is not advised during pregnancy at any stage.International label, same formulation · Base de données publique des médicaments (ANSM)
• Use during breast-feeding is not advised.International label, same formulation · Base de données publique des médicaments (ANSM)

• Dipotassium clorazepate: Benzodiazepine acting as a specific agonist at the central GABA-omega (BZ1/BZ2) receptor complex, modulating chloride-channel opening; about 80% is decarboxylated in the stomach to the active metabolite desmethyldiazepam (half-life 30-150 h).