سعر كالمتانيل 1.5 مجم 30 قرص 2022

Calmetanil 1.5mg 30 f.c. tab.: Bromazepam (Mepaco / Spimaco Misr).

• Health Canada PM: short-term symptomatic relief of manifestations of excessive anxiety in anxiety neurosis.Health Canada Drug Product Database

• Health Canada PM: most frequent — drowsiness, ataxia, dizziness; also headache, confusion, paradoxical behavioural effects, dependence/withdrawal, respiratory depression, rash, visual disturbance.International label, equivalent formulation · Health Canada Drug Product Database

• Health Canada PM: hypersensitivity to benzodiazepines or excipients; myasthenia gravis; severe hepatic impairment; severe respiratory insufficiency; sleep apnea syndrome; narrow-angle glaucoma.International label, equivalent formulation · Health Canada Drug Product Database

• Health Canada PM boxed warnings: addiction, abuse and misuse; severe withdrawal if stopped abruptly — taper; concomitant opioids may cause profound sedation, respiratory depression, coma or death.International label, equivalent formulation · Health Canada Drug Product Database
• Health Canada PM: avoid alcohol/other CNS depressants; risk of falls/fractures; anterograde amnesia; paradoxical reactions; not for depressive or psychotic disorders; lactose intolerance caution.International label, equivalent formulation · Health Canada Drug Product Database

• OpioidsMajorProfound sedation, respiratory depression, coma and death — reserve concomitant use; limit dose/duration; monitor.Health Canada Drug Product Database
• Alcohol and other CNS depressantsMajorAdditive sedation and cardio-respiratory depression.Health Canada Drug Product Database
• FluvoxamineMajorSignificantly increased bromazepam exposure (≈2.4× AUC) and longer half-life.Health Canada Drug Product Database

• Health Canada PM: safety in pregnancy not established; should not be used during pregnancy; late-pregnancy use may cause neonatal hypotonia, hypothermia, respiratory depression, poor feeding and withdrawal.International label, equivalent formulation · Health Canada Drug Product Database
• Health Canada PM: bromazepam and metabolites are probably excreted in human milk; do not give to nursing mothers.International label, equivalent formulation · Health Canada Drug Product Database

• Bromazepam: Binds GABA-A benzodiazepine site, facilitating GABA-mediated chloride influx and neuronal hyperpolarization (anxiolytic/sedative/muscle-relaxant class effects).