سعر Adwitine 30 mg 30 capsules 2026

• Serious adverse reactions described in the label include suicidality, hepatotoxicity, orthostatic hypotension, serotonin syndrome, bleeding, severe skin reactions and discontinuation syndrome; common reactions include nausea, dry mouth, somnolence, constipation, decreased appetite and hyperhidrosis.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Use with MAOIs for psychiatric disorders, or within 5 days of stopping duloxetine or 14 days of stopping an MAOI, is contraindicated (serotonin syndrome); starting duloxetine in patients on linezolid or IV methylene blue is contraindicated.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Boxed warning: antidepressants increased the risk of suicidal thoughts and behaviours in children, adolescents and young adults; monitor all patients closely for worsening and emergence of suicidal thoughts.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Hepatotoxicity (sometimes fatal hepatic failure) has been reported; avoid in substantial alcohol use or chronic liver disease. Other warnings: orthostatic hypotension/falls, serotonin syndrome, increased bleeding risk, severe skin reactions, discontinuation syndrome, mania, angle-closure glaucoma.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Potent CYP1A2 inhibitors (e.g. fluvoxamine, ciprofloxacin)Avoid: fluvoxamine increased duloxetine AUC about 6-fold.DailyMed (U.S. National Library of Medicine)
• CYP2D6 substrates/inhibitorsPotent CYP2D6 inhibitors may raise duloxetine levels; duloxetine is a moderate CYP2D6 inhibitor.DailyMed (U.S. National Library of Medicine)

• Use in the month before delivery may be associated with an increased risk of postpartum haemorrhage; published data have not identified a clear drug-associated risk of major birth defects. A pregnancy exposure registry exists.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Duloxetine is present in human milk; sedation, poor feeding and poor weight gain have been reported in exposed infants, who should be monitored.International label, same formulation · DailyMed (U.S. National Library of Medicine)

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